E-ISSN 2146-8362
 

Original Research 


Prognostic Implication of MYb-Like, Swirm and Mpn Domain-Containing Protein-1 and Twist-1 in Renal Cell Carcinoma

Ola Harb, Abdelmonem Hegazy, Maged Ali, Rasha Haggag.

Cited by (2)

Abstract
Objective: The data available regarding the epithelial-mesenchymal transition (EMT) markers are little. This study aimed to evaluate the immunohistochemical expression of EMT markers; MYb-like, Swirm and Mpn domain-containing protein-1 (MYSM-1) and Twist-1 in renal cell carcinoma (RCC), in a trial to find their role in the prognosis of such type of cancer.
Methods: Immunoexpressions of MYb-like, Swirm and Mpn domaincontaining protein-1 (MYSM-1) and Twist-1 were assessed in tissue specimens of 50 patients with RCC, and correlated with other clinicopathological features. The findings and their correlations were statistically determined.
Results: Low expression of MYSM-1 was negatively correlated with size of the tumor, primary tumor (pT) stage, Fuhrman grade (P < 0.001), age (P = 0.002), and lymph node metastases (P = 0.010). Immunoexpression of MYSM-1 was significantly correlated with distant metastases (P = 0.004), overall survival (OS) (P < 0.001), and local recurrence (P = 0.001). High expression of Twist-1 was positively correlated with pT stage, Fuhrman grade, lymph node, distant metastases, age (P < 0.001), clinical stage (P = 0.002), the
presence of sarcomatous change (P = 0.004), and tumor size (P = 0.008). Immunoexpression of Twist-1 was significantly correlated with distant metastases (P = 0.009), OS (P < 0.001), and local recurrence (P = 0.003).
Conclusion: Overexpression of Twist-1 is an indication of poor prognosis in patients with RCC, whereas that of MYSM-1 is a marker of good prognosis.

Key words: Renal cell carcinoma, Immunohistochemical expression, MYSM-1, Twist-1, Prognosis


 
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This Article Cited By the following articles

Cytoplasmic expression of Twist1, an EMT-related transcription factor, is associated with higher grades renal cell carcinomas and worse progression-free survival in clear cell renal cell carcinoma
Clin Exp Med 2018; 18(2): 177.

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Cytoplasmic expression of Twist1, an EMT-related transcription factor, is associated with higher grades renal cell carcinomas and worse progression-free survival in clear cell renal cell carcinoma
Clin Exp Med 2017; (): .

2
 
How to Cite this Article
Pubmed Style

Harb O, Hegazy A, Ali M, Haggag R. Prognostic Implication of MYb-Like, Swirm and Mpn Domain-Containing Protein-1 and Twist-1 in Renal Cell Carcinoma. J Interdiscip Histopathol. 2016; 4(1): 1-8. doi:10.5455/jihp.20160226125558


Web Style

Harb O, Hegazy A, Ali M, Haggag R. Prognostic Implication of MYb-Like, Swirm and Mpn Domain-Containing Protein-1 and Twist-1 in Renal Cell Carcinoma. http://www.ejmjih.com/?mno=216352 [Access: October 18, 2018]. doi:10.5455/jihp.20160226125558


AMA (American Medical Association) Style

Harb O, Hegazy A, Ali M, Haggag R. Prognostic Implication of MYb-Like, Swirm and Mpn Domain-Containing Protein-1 and Twist-1 in Renal Cell Carcinoma. J Interdiscip Histopathol. 2016; 4(1): 1-8. doi:10.5455/jihp.20160226125558



Vancouver/ICMJE Style

Harb O, Hegazy A, Ali M, Haggag R. Prognostic Implication of MYb-Like, Swirm and Mpn Domain-Containing Protein-1 and Twist-1 in Renal Cell Carcinoma. J Interdiscip Histopathol. (2016), [cited October 18, 2018]; 4(1): 1-8. doi:10.5455/jihp.20160226125558



Harvard Style

Harb, O., Hegazy, A., Ali, M. & Haggag, R. (2016) Prognostic Implication of MYb-Like, Swirm and Mpn Domain-Containing Protein-1 and Twist-1 in Renal Cell Carcinoma. J Interdiscip Histopathol, 4 (1), 1-8. doi:10.5455/jihp.20160226125558



Turabian Style

Harb, Ola, Abdelmonem Hegazy, Maged Ali, and Rasha Haggag. 2016. Prognostic Implication of MYb-Like, Swirm and Mpn Domain-Containing Protein-1 and Twist-1 in Renal Cell Carcinoma. Journal of Interdisciplinary Histopathology, 4 (1), 1-8. doi:10.5455/jihp.20160226125558



Chicago Style

Harb, Ola, Abdelmonem Hegazy, Maged Ali, and Rasha Haggag. "Prognostic Implication of MYb-Like, Swirm and Mpn Domain-Containing Protein-1 and Twist-1 in Renal Cell Carcinoma." Journal of Interdisciplinary Histopathology 4 (2016), 1-8. doi:10.5455/jihp.20160226125558



MLA (The Modern Language Association) Style

Harb, Ola, Abdelmonem Hegazy, Maged Ali, and Rasha Haggag. "Prognostic Implication of MYb-Like, Swirm and Mpn Domain-Containing Protein-1 and Twist-1 in Renal Cell Carcinoma." Journal of Interdisciplinary Histopathology 4.1 (2016), 1-8. Print. doi:10.5455/jihp.20160226125558



APA (American Psychological Association) Style

Harb, O., Hegazy, A., Ali, M. & Haggag, R. (2016) Prognostic Implication of MYb-Like, Swirm and Mpn Domain-Containing Protein-1 and Twist-1 in Renal Cell Carcinoma. Journal of Interdisciplinary Histopathology, 4 (1), 1-8. doi:10.5455/jihp.20160226125558





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