E-ISSN 2146-8362
 

Original Research 


Expression of CA125 in Tissue and Serum of Uterine Serous Carcinoma Patients

Joseph Menczer, Letizia Schreiber, Esther Berger, Tally Levy.

Abstract
Objective: To compare tissue immunohistochemical expression of CA125 with its level in the serum of corresponding uterine serous carcinoma (USC) patients.
Materials and Methods: Paraffin-embedded tissue blocks of consecutive USC uterine specimens of 25 patients with known serum CA125 levels prior to treatment were examined. The clinicopathological records of these patients were retrospectively abstracted. Immunohistochemistry was performed in each case on deparaffinized 4μ sections of paraffin-embedded tissue blocks for detection of CA125. Staining of more than 10% of cells was considered positive. A scoring index was calculated by multiplying the intensity grade by the percentage of stained cells and considered low when it was equal to 1 or less and high when it was more than 1. Results: Positive immunohistochemical staining and a high staining score were found in 72.0% and 61.1% of the patients respectively elevated serum CA125 levels prior to treatment were observed in 36.0% of the patients. The difference between the percentage of USC patients with positive CA125 tissue staining and the percentage of those with elevated CA125 serum levels were significant. Elevated serum levels correlated significantly with advanced stage disease. No correlation was found between positive immunohistochemical tissue staining parameters and stage of the disease.
Conclusion: The higher proportion of USC patients with positive CA125 immunohistochemical tissue staining than with elevated serum CA125 levels indicates the presence of some mechanism that prevents the access of CA125 into the circulation.

Key words: Uterine serous carcinoma, CA125 immunohistochemical tissue staining, CA125 serum levels


 
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REFERENCES
1. del Carmen MG, Birrer M, Schorge JO. Uterine papillary serous cancer: A review of the literature. Gynecol Oncol 2012;127:651-61. [DOI via Crossref]    [Pubmed]   
2. Fader AN, Santin AD, Gehrig PA. Early stage uterine serous carcinoma: Management updates and genomic advances. Gynecol Oncol 2013;129:244-50. [DOI via Crossref]    [Pubmed]   
3. Tseng PC, Sprance HE, Carcangiu ML, Chambers JT, Schwartz PE. CA 125, NB/70K, and lipid-associated sialic acid in monitoring uterine papillary serous carcinoma. Obstet Gynecol 1989;74:384-7. [Pubmed]   
4. Price FV, Chambers SK, Carcangiu ML, Kohorn EI, Schwartz PE, Chambers JT. CA 125 may not reflect disease status in patients with uterine serous carcinoma. Cancer 1998;82:1720-5. [DOI via Crossref]   
5. Olawaiye AB, Rauh-Hain JA, Withiam-Leitch M, Rueda B, Goodman A, del Carmen MG. Utility of pre-operative serum CA-125 in the management of uterine papillary serous carcinoma. Gynecol Oncol 2008;110:293-8. [DOI via Crossref]    [Pubmed]   
6. Hoskins PJ, Le N, Correa R. CA 125 normalization with chemotherapy is independently predictive of survival in advanced endometrial cancer. Gynecol Oncol 2011;120:52-5. [DOI via Crossref]    [Pubmed]   
7. Roelofsen T, Mingels M, Hendriks JC, Samlal RA, Snijders MP, Aalders AL, et al. Preoperative CA-125 predicts extra-uterine disease and survival in uterine papillary serous carcinoma patients. Int J Biol Markers 2012;27:e263-71. [DOI via Crossref]    [Pubmed]   
8. Gupta D, Gunter MJ, Yang K, Lee S, Zuckerwise L, Chen LM, et al. Performance of serum CA125 as a prognostic biomarker in patients with uterine papillary serous carcinoma 2011;21:529-34.
9. Frimer M, Hou JY, McAndrew TC, Goldberg GL, Shahabi S. The clinical relevance of rising CA-125 levels within the normal range in patients with uterine papillary serous cancer. Reprod Sci 2013;20:449-55. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
10. Abramovich D, Markman M, Kennedy A, Webster K, Belinson J. Serum CA-125 as a marker of disease activity in uterine papillary serous carcinoma. J Cancer Res Clin Oncol 1999;125:697-8. [DOI via Crossref]    [Pubmed]   
11. Nur S, Chuang L, Ramaswamy G. Immunohistochemical characterization of cancer antigen in uterine cancers. Int J Gynecol Cancer 2006;16:1903-10. [DOI via Crossref]    [Pubmed]   
12. Yamazawa K, Hirashiki K, Usui H, Mitsuhashi A, Matsui H, Sekiya S. Discordance between serum level and tissue immunohistochemical staining of CA125 in endometrioid adenocarcinoma of the uterine corpus. Int J Gynecol Pathol 2005;24:254-9. [DOI via Crossref]    [Pubmed]   
13. Ginath S, Menczer J, Fintsi Y, Ben-Shem E, Glezerman M, Avinoach I. Tissue and serum CA125 expression in endometrial cancer. Int J Gynecol Cancer 2002;12:372-5. [DOI via Crossref]    [Pubmed]   

How to Cite this Article
Pubmed Style

Menczer J, Schreiber L, Berger E, Levy T. Expression of CA125 in Tissue and Serum of Uterine Serous Carcinoma Patients. J Interdiscip Histopathol. 2015; 3(3): 102-104. doi:10.5455/jihp.20150713121418


Web Style

Menczer J, Schreiber L, Berger E, Levy T. Expression of CA125 in Tissue and Serum of Uterine Serous Carcinoma Patients. http://www.ejmjih.com/?mno=192104 [Access: August 16, 2018]. doi:10.5455/jihp.20150713121418


AMA (American Medical Association) Style

Menczer J, Schreiber L, Berger E, Levy T. Expression of CA125 in Tissue and Serum of Uterine Serous Carcinoma Patients. J Interdiscip Histopathol. 2015; 3(3): 102-104. doi:10.5455/jihp.20150713121418



Vancouver/ICMJE Style

Menczer J, Schreiber L, Berger E, Levy T. Expression of CA125 in Tissue and Serum of Uterine Serous Carcinoma Patients. J Interdiscip Histopathol. (2015), [cited August 16, 2018]; 3(3): 102-104. doi:10.5455/jihp.20150713121418



Harvard Style

Menczer, J., Schreiber, L., Berger, E. & Levy, T. (2015) Expression of CA125 in Tissue and Serum of Uterine Serous Carcinoma Patients. J Interdiscip Histopathol, 3 (3), 102-104. doi:10.5455/jihp.20150713121418



Turabian Style

Menczer, Joseph, Letizia Schreiber, Esther Berger, and Tally Levy. 2015. Expression of CA125 in Tissue and Serum of Uterine Serous Carcinoma Patients. Journal of Interdisciplinary Histopathology, 3 (3), 102-104. doi:10.5455/jihp.20150713121418



Chicago Style

Menczer, Joseph, Letizia Schreiber, Esther Berger, and Tally Levy. "Expression of CA125 in Tissue and Serum of Uterine Serous Carcinoma Patients." Journal of Interdisciplinary Histopathology 3 (2015), 102-104. doi:10.5455/jihp.20150713121418



MLA (The Modern Language Association) Style

Menczer, Joseph, Letizia Schreiber, Esther Berger, and Tally Levy. "Expression of CA125 in Tissue and Serum of Uterine Serous Carcinoma Patients." Journal of Interdisciplinary Histopathology 3.3 (2015), 102-104. Print. doi:10.5455/jihp.20150713121418



APA (American Psychological Association) Style

Menczer, J., Schreiber, L., Berger, E. & Levy, T. (2015) Expression of CA125 in Tissue and Serum of Uterine Serous Carcinoma Patients. Journal of Interdisciplinary Histopathology, 3 (3), 102-104. doi:10.5455/jihp.20150713121418





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