Vaginal Mucosa Melanoma With Giant Cell Phenotype: A Case Report

Abstract

Saulo Mendoza-Ramírez*, Saray Betsabe Santos Torres, Leonora Chávez Mercado, Lourdes Lucía Morales-Jáuregui, Marco Antonio Olvera-Olvera and Mario Murguia-Perez*

Melanomas are malignant tumors that arise from pigmented cells, melanocytes. In the female genital tract, they represent 18% of all mucosal melanomas. The first vaginal melanoma was described in 1887, and approximately 500 cases have recently been documented in the literature. Currently, vaginal melanoma represents <5.5% of all vaginal neoplasms and 0.4 to 0.8% of all melanomas in women. We present the case of a 60 year-old woman with transvaginal bleeding and dysuria. Colposcopy reported< an exophytic lesion located on the anterior vaginal wall, pigmented and bleeding upon contact. The clinical diagnosis was cervical carcinoma, a biopsy was taken and sent to the Surgical Pathology service where the histopathological diagnosis of melanoma with multinucleated giant cell phenotype of the vaginal mucosa was concluded, it also presented pigmentation and osteoid stromal metaplasia.