E-ISSN 2146-8362
 

Original Research 


Predictive role of REG IV and YKL-40 in locally advanced rectal cancer patients receiving neoadjuvant chemoradiotherapy

Nehal S Abouhashem, Eman H Abdelbary, Mohamed Abdelgawad.

Abstract
Abstract
Objective: Patients with locally advanced rectal cancer (LARC) need extensive surgical interference. Preoperative neoadjuvant chemoradiotherapy (CRT) shifts this extensive surgical procedure to another sphincter saving one as well as lowers patient's morbidity and mortality. Till now, there is no definite method to predict patients' response to neoadjuvant CRT.
Methods: REG IV and YKL-40 immunohistochemistry was evaluated in pre-treatment endoscopic biopsies from 42 LARC cases who received neoadjuvant CRT followed by surgical interference. The findings were correlated with the clinico-pathological features, tumor response and tumor regression grade of the post-operative specimens.
Results: REG IV high expression was associated with advanced post-treatment pathological tumor status, post -treatment pathological nodal status and presence of lympho-vascular invasion with statistical significance. Furthermore, it was correlated with a lower extent of tumor regression after neoadjuvant CRT. All patients with pCR exhibited negative/low REG IV expression and only 13.6% of the responders showed high REG IV expression with statistical significance. YKL-40 immunohistochemical expression was highly associated with the tumor regression rate where 85% of LARC patients with poor neoadjuvant CRT response highly expressed YKL-40 and 66.6% of patients with complete regression showed negativelow expression of YKL-40.
Conclusion: Our findings implicate REG IV and YKL-40 as important predictors of neoadjuvant CRT response in locally advanced rectal cancer.

Key words: Locally advanced rectal cancer, predictive role, REG IV, YKL 40, neoadjuvant chemoradiotherapy .


 
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Pubmed Style

Abouhashem NS, Abdelbary EH, Abdelgawad M. Predictive role of REG IV and YKL-40 in locally advanced rectal cancer patients receiving neoadjuvant chemoradiotherapy. J Interdiscip Histopathol. 2018; 6(1): 15-25. doi:10.5455/jihp.20180407065848


Web Style

Abouhashem NS, Abdelbary EH, Abdelgawad M. Predictive role of REG IV and YKL-40 in locally advanced rectal cancer patients receiving neoadjuvant chemoradiotherapy. http://www.ejmjih.com/?mno=294163 [Access: August 16, 2018]. doi:10.5455/jihp.20180407065848


AMA (American Medical Association) Style

Abouhashem NS, Abdelbary EH, Abdelgawad M. Predictive role of REG IV and YKL-40 in locally advanced rectal cancer patients receiving neoadjuvant chemoradiotherapy. J Interdiscip Histopathol. 2018; 6(1): 15-25. doi:10.5455/jihp.20180407065848



Vancouver/ICMJE Style

Abouhashem NS, Abdelbary EH, Abdelgawad M. Predictive role of REG IV and YKL-40 in locally advanced rectal cancer patients receiving neoadjuvant chemoradiotherapy. J Interdiscip Histopathol. (2018), [cited August 16, 2018]; 6(1): 15-25. doi:10.5455/jihp.20180407065848



Harvard Style

Abouhashem, N. S., Abdelbary, E. H. & Abdelgawad, M. (2018) Predictive role of REG IV and YKL-40 in locally advanced rectal cancer patients receiving neoadjuvant chemoradiotherapy. J Interdiscip Histopathol, 6 (1), 15-25. doi:10.5455/jihp.20180407065848



Turabian Style

Abouhashem, Nehal S, Eman H Abdelbary, and Mohamed Abdelgawad. 2018. Predictive role of REG IV and YKL-40 in locally advanced rectal cancer patients receiving neoadjuvant chemoradiotherapy. Journal of Interdisciplinary Histopathology, 6 (1), 15-25. doi:10.5455/jihp.20180407065848



Chicago Style

Abouhashem, Nehal S, Eman H Abdelbary, and Mohamed Abdelgawad. "Predictive role of REG IV and YKL-40 in locally advanced rectal cancer patients receiving neoadjuvant chemoradiotherapy." Journal of Interdisciplinary Histopathology 6 (2018), 15-25. doi:10.5455/jihp.20180407065848



MLA (The Modern Language Association) Style

Abouhashem, Nehal S, Eman H Abdelbary, and Mohamed Abdelgawad. "Predictive role of REG IV and YKL-40 in locally advanced rectal cancer patients receiving neoadjuvant chemoradiotherapy." Journal of Interdisciplinary Histopathology 6.1 (2018), 15-25. Print. doi:10.5455/jihp.20180407065848



APA (American Psychological Association) Style

Abouhashem, N. S., Abdelbary, E. H. & Abdelgawad, M. (2018) Predictive role of REG IV and YKL-40 in locally advanced rectal cancer patients receiving neoadjuvant chemoradiotherapy. Journal of Interdisciplinary Histopathology, 6 (1), 15-25. doi:10.5455/jihp.20180407065848





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