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Case Report Open Access


Mammary Leiomyomatous-Type Myofibroblastoma with Symplastic Atypia

Michal Zamecnik, Karol Macuch.

Abstract
An unusual case of leiomyomatous-type mammary myofibroblastoma (MFB) with symplastic nuclear atypia is described in this report. The tumor occurred in a 67-year-old woman as a palpable 1 cm nodule. Histologically, the lesion was composed of myoid-appearing spindle cell fascicles with immunohistochemical positivity for CD34, Bcl-2, smooth muscle actin, desmin, h-caldesmon, calponin, estrogen receptor, p16, and cyclin-D1. Many tumor cells exhibited nuclear atypia resembling closely that of atypical (bizarre, symplastic) leiomyoma of the uterus. Mitotic activity was very low and MIB-1 index was 3%. Leiomyomatous MFB with atypia mimics malignant lesions which has to be considered in differential diagnosis.

Key words: Atypical leiomyoma, breast, immunohistochemistry, myofibroblastoma, uterus


 
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Pubmed Style

Zamecnik M, Macuch K. Mammary Leiomyomatous-Type Myofibroblastoma with Symplastic Atypia. J Interdiscipl Histopathol. 2017; 5(3): 103-105. doi:10.5455/jihp.20170326021845


Web Style

Zamecnik M, Macuch K. Mammary Leiomyomatous-Type Myofibroblastoma with Symplastic Atypia. http://www.ejmjih.com/?mno=257249 [Access: February 21, 2018]. doi:10.5455/jihp.20170326021845


AMA (American Medical Association) Style

Zamecnik M, Macuch K. Mammary Leiomyomatous-Type Myofibroblastoma with Symplastic Atypia. J Interdiscipl Histopathol. 2017; 5(3): 103-105. doi:10.5455/jihp.20170326021845



Vancouver/ICMJE Style

Zamecnik M, Macuch K. Mammary Leiomyomatous-Type Myofibroblastoma with Symplastic Atypia. J Interdiscipl Histopathol. (2017), [cited February 21, 2018]; 5(3): 103-105. doi:10.5455/jihp.20170326021845



Harvard Style

Zamecnik, M. & Macuch, K. (2017) Mammary Leiomyomatous-Type Myofibroblastoma with Symplastic Atypia. J Interdiscipl Histopathol, 5 (3), 103-105. doi:10.5455/jihp.20170326021845



Turabian Style

Zamecnik, Michal, and Karol Macuch. 2017. Mammary Leiomyomatous-Type Myofibroblastoma with Symplastic Atypia. Journal of Interdisciplinary Histopathology, 5 (3), 103-105. doi:10.5455/jihp.20170326021845



Chicago Style

Zamecnik, Michal, and Karol Macuch. "Mammary Leiomyomatous-Type Myofibroblastoma with Symplastic Atypia." Journal of Interdisciplinary Histopathology 5 (2017), 103-105. doi:10.5455/jihp.20170326021845



MLA (The Modern Language Association) Style

Zamecnik, Michal, and Karol Macuch. "Mammary Leiomyomatous-Type Myofibroblastoma with Symplastic Atypia." Journal of Interdisciplinary Histopathology 5.3 (2017), 103-105. Print. doi:10.5455/jihp.20170326021845



APA (American Psychological Association) Style

Zamecnik, M. & Macuch, K. (2017) Mammary Leiomyomatous-Type Myofibroblastoma with Symplastic Atypia. Journal of Interdisciplinary Histopathology, 5 (3), 103-105. doi:10.5455/jihp.20170326021845





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