E-ISSN 2146-8362
 

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Histopathological Effects of Varied Fluoride Concentration on Cerebrum in Albino Rats

Sajad Hamid, Zaffar Kawoosa, Shahnawaz Hamid, M.A. Mir, Athar Hafiz, Irfan Jan, Fayiza Yaqoob.

Cited by (2)

Abstract
Fluorides have been a cause of concern for scientists and environmentalists for the long because of their harmful effects on the human and animal life but the problem was highlighted during the twentieth century because of great increase in the human population and industrialization. Since fluorides accumulate in calcified and hard tissues of the body such as bone and teeth and can be detected easily in these tissues, so most of the previous studies focused on the effects of fluorides on these tissues. However, during the past decade researchers all over the world have felt that there is a need to study the effects of fluorides on various other tissues of the body including CNS as fluoride intake for prolonged period is known to cause abnormal behavioural pattern, grave implications for Alzheimer’s Disease, Dementia, Attention deficit disorder and reduced I.Q in children as the fluorides are known to cross blood brain barrier. Hence the present study has thrown light on the involvement of brain in chronic fluoride toxicity. The target organ of studied was cerebrum. In the Study, albino rats were exposed to 30 or 100 ppm fluoride (asNaF) in drinking water for 3 months. Rats exposed to 30 ppm fluoride did not show any notable alterations in brain histology, whereas rats exposed to 100 ppm fluoride showed significant neurodegenerative changes in lhe motor cortex.Changes included decrease in size and number of neurons in all the regions, signs of chromatolysis and gliosis in the motor cortex. These histological changes suggest a toxic effect of high-fluoride intake & on chronic use.

Key words: Albino rats, histology, Cerebrum, Fluoride, Intoxication


 
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This Article Cited By the following articles

Sodium fluoride does not affect the working memory and number of pyramidal cells in rat medial prefrontal cortex
Anat Sci Int 2018; 93(1): 128.

1
 
Sodium fluoride does not affect the working memory and number of pyramidal cells in rat medial prefrontal cortex
Anat Sci Int 2016; (): .

2
 

How to Cite this Article
Pubmed Style

Hamid S, Kawoosa Z, Hamid S, Mir M, Hafiz A, Jan I, Yaqoob . Histopathological Effects of Varied Fluoride Concentration on Cerebrum in Albino Rats. J Interdiscip Histopathol. 2012; 1(1): 30-34. doi:10.5455/jihp.20121105123701


Web Style

Hamid S, Kawoosa Z, Hamid S, Mir M, Hafiz A, Jan I, Yaqoob . Histopathological Effects of Varied Fluoride Concentration on Cerebrum in Albino Rats. http://www.ejmjih.com/?mno=25280 [Access: May 21, 2018]. doi:10.5455/jihp.20121105123701


AMA (American Medical Association) Style

Hamid S, Kawoosa Z, Hamid S, Mir M, Hafiz A, Jan I, Yaqoob . Histopathological Effects of Varied Fluoride Concentration on Cerebrum in Albino Rats. J Interdiscip Histopathol. 2012; 1(1): 30-34. doi:10.5455/jihp.20121105123701



Vancouver/ICMJE Style

Hamid S, Kawoosa Z, Hamid S, Mir M, Hafiz A, Jan I, Yaqoob . Histopathological Effects of Varied Fluoride Concentration on Cerebrum in Albino Rats. J Interdiscip Histopathol. (2012), [cited May 21, 2018]; 1(1): 30-34. doi:10.5455/jihp.20121105123701



Harvard Style

Hamid, S., Kawoosa, Z., Hamid, S., Mir, M., Hafiz, A., Jan, I. & Yaqoob, . (2012) Histopathological Effects of Varied Fluoride Concentration on Cerebrum in Albino Rats. J Interdiscip Histopathol, 1 (1), 30-34. doi:10.5455/jihp.20121105123701



Turabian Style

Hamid, Sajad, Zaffar Kawoosa, Shahnawaz Hamid, M.A. Mir, Athar Hafiz, Irfan Jan, and Fayiza Yaqoob. 2012. Histopathological Effects of Varied Fluoride Concentration on Cerebrum in Albino Rats. Journal of Interdisciplinary Histopathology, 1 (1), 30-34. doi:10.5455/jihp.20121105123701



Chicago Style

Hamid, Sajad, Zaffar Kawoosa, Shahnawaz Hamid, M.A. Mir, Athar Hafiz, Irfan Jan, and Fayiza Yaqoob. "Histopathological Effects of Varied Fluoride Concentration on Cerebrum in Albino Rats." Journal of Interdisciplinary Histopathology 1 (2012), 30-34. doi:10.5455/jihp.20121105123701



MLA (The Modern Language Association) Style

Hamid, Sajad, Zaffar Kawoosa, Shahnawaz Hamid, M.A. Mir, Athar Hafiz, Irfan Jan, and Fayiza Yaqoob. "Histopathological Effects of Varied Fluoride Concentration on Cerebrum in Albino Rats." Journal of Interdisciplinary Histopathology 1.1 (2012), 30-34. Print. doi:10.5455/jihp.20121105123701



APA (American Psychological Association) Style

Hamid, S., Kawoosa, Z., Hamid, S., Mir, M., Hafiz, A., Jan, I. & Yaqoob, . (2012) Histopathological Effects of Varied Fluoride Concentration on Cerebrum in Albino Rats. Journal of Interdisciplinary Histopathology, 1 (1), 30-34. doi:10.5455/jihp.20121105123701





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