E-ISSN 2146-8362
 

Original Research 


The Administration of Hydroethanolic Extract of Cordia Ecalyculata Vell., At Different Doses, Promotes Reproductive Toxicity in Adult Male Rats

Lucas Giglio Colli, Mirian Campos dos Santos, Jessica Tambor, Isabel Cristina Cherici Camargo.

Abstract
Popular use of Cordia ecalyculata extract is increasing due to its potential in inhibiting appetite. Its side effects on reproduction have not yet been reported. Thus, for the first time, this study investigated the potential reproductive toxicity of different doses of C. ecalyculata extract in adult male rats (n = 12/group), which received hydroethanolic extract of C. ecalyculata at 20, 100, or 400 mg/kg of body weight (b.w.) or distilled water (control group), orally (gavage) for 60 consecutive days. The testicular and epididymal tissue, sperm morphology, fertility, and pregnancy outcome were evaluated. The results showed that food consumption decreased significantly in the groups that received 20 or 400 mg/kg of extract, but b.w. was similar (P > 0.05) in all experimental groups. No significant alteration was observed in testicular weight. At the 400 mg/kg dose, the epididymal relative weight increased (P < 0.05), compared to the control group. There were several histopathological changes in testes and epididymis at all extract doses. In addition, the percentage of abnormal gametes increased (P < 0.05) and the gestation rate decreased (P < 0.05). In conclusion, the C. ecalyculata extract promotes reproductive toxicity in rats, but with no dose-dependent effect.

Key words: Cordia ecalyculata; testis; epididymis; gametes; fertility.


 
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Pubmed Style

Lucas Giglio Colli, Mirian Campos dos Santos, Jessica Tambor, Isabel Cristina Cherici Camargo. The Administration of Hydroethanolic Extract of Cordia Ecalyculata Vell., At Different Doses, Promotes Reproductive Toxicity in Adult Male Rats. J Interdiscip Histopathol. 2016; 4(4): 93-98. doi:10.5455/jihp.20160706103059


Web Style

Lucas Giglio Colli, Mirian Campos dos Santos, Jessica Tambor, Isabel Cristina Cherici Camargo. The Administration of Hydroethanolic Extract of Cordia Ecalyculata Vell., At Different Doses, Promotes Reproductive Toxicity in Adult Male Rats. http://www.ejmjih.com/?mno=230203 [Access: December 19, 2018]. doi:10.5455/jihp.20160706103059


AMA (American Medical Association) Style

Lucas Giglio Colli, Mirian Campos dos Santos, Jessica Tambor, Isabel Cristina Cherici Camargo. The Administration of Hydroethanolic Extract of Cordia Ecalyculata Vell., At Different Doses, Promotes Reproductive Toxicity in Adult Male Rats. J Interdiscip Histopathol. 2016; 4(4): 93-98. doi:10.5455/jihp.20160706103059



Vancouver/ICMJE Style

Lucas Giglio Colli, Mirian Campos dos Santos, Jessica Tambor, Isabel Cristina Cherici Camargo. The Administration of Hydroethanolic Extract of Cordia Ecalyculata Vell., At Different Doses, Promotes Reproductive Toxicity in Adult Male Rats. J Interdiscip Histopathol. (2016), [cited December 19, 2018]; 4(4): 93-98. doi:10.5455/jihp.20160706103059



Harvard Style

Lucas Giglio Colli, Mirian Campos dos Santos, Jessica Tambor, Isabel Cristina Cherici Camargo (2016) The Administration of Hydroethanolic Extract of Cordia Ecalyculata Vell., At Different Doses, Promotes Reproductive Toxicity in Adult Male Rats. J Interdiscip Histopathol, 4 (4), 93-98. doi:10.5455/jihp.20160706103059



Turabian Style

Lucas Giglio Colli, Mirian Campos dos Santos, Jessica Tambor, Isabel Cristina Cherici Camargo. 2016. The Administration of Hydroethanolic Extract of Cordia Ecalyculata Vell., At Different Doses, Promotes Reproductive Toxicity in Adult Male Rats. Journal of Interdisciplinary Histopathology, 4 (4), 93-98. doi:10.5455/jihp.20160706103059



Chicago Style

Lucas Giglio Colli, Mirian Campos dos Santos, Jessica Tambor, Isabel Cristina Cherici Camargo. "The Administration of Hydroethanolic Extract of Cordia Ecalyculata Vell., At Different Doses, Promotes Reproductive Toxicity in Adult Male Rats." Journal of Interdisciplinary Histopathology 4 (2016), 93-98. doi:10.5455/jihp.20160706103059



MLA (The Modern Language Association) Style

Lucas Giglio Colli, Mirian Campos dos Santos, Jessica Tambor, Isabel Cristina Cherici Camargo. "The Administration of Hydroethanolic Extract of Cordia Ecalyculata Vell., At Different Doses, Promotes Reproductive Toxicity in Adult Male Rats." Journal of Interdisciplinary Histopathology 4.4 (2016), 93-98. Print. doi:10.5455/jihp.20160706103059



APA (American Psychological Association) Style

Lucas Giglio Colli, Mirian Campos dos Santos, Jessica Tambor, Isabel Cristina Cherici Camargo (2016) The Administration of Hydroethanolic Extract of Cordia Ecalyculata Vell., At Different Doses, Promotes Reproductive Toxicity in Adult Male Rats. Journal of Interdisciplinary Histopathology, 4 (4), 93-98. doi:10.5455/jihp.20160706103059





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