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Case Report Open Access


Proliferative Verrucous Leukoplakia: A Case Report with Emphasis on Diagnosis and Treatment

Bhagyalaxmi Hongal, Priya Shirish Joshi, Appasaheb Sanadi.

Abstract
Proliferative verrucous leukoplakia (PVL) is characterized by development of multiple keratotic plaques with roughened surface projections. Since its introduction in 1985 by Hansen et al., PVL of the oral mucosa still remains an enigma and is difficult to define as a sub-entity of leukoplakia. Although the lesion typically begins as simple, flat hyperkeratosis indistinguishable from ordinary leukoplakic lesion, PVL exhibits persistent growth and eventually becomes exophytic and verrucous in nature. As the lesion progresses, they may go through a stage indistinguishable from verrucous carcinoma but may later develop dysplastic changes or transform into full-fledged squamous cell carcinoma usually within 8 years of initial PVL diagnosis. PVL is unusual among the leukoplakia variants in having a strong female predilection and minimal association with tobacco usage. Presenting here, a case of PVL transforming into verrucous carcinoma with areas of suspected malignancy in a 53-year-old male with habit of chewing tobacco quid and beedi smoking 4-6 times a day since 20 years, with a chief complaint of pain and burning sensation of the oral cavity and multiple oral lesions for 1 month. This paper will elaborate typical behavior pattern of the lesion and will discuss this rare entity in light of current information.

Key words: Leukoplakia, Oral cancer, Proliferative verrucous leukoplakia, Squamous cell carcinoma, Verrucous carcinoma.


 
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How to Cite this Article
Pubmed Style

Hongal B, Joshi PS, Sanadi A. Proliferative Verrucous Leukoplakia: A Case Report with Emphasis on Diagnosis and Treatment. J Interdiscipl Histopathol. 2016; 4(4): 110-113. doi:10.5455/jihp.20161019105523


Web Style

Hongal B, Joshi PS, Sanadi A. Proliferative Verrucous Leukoplakia: A Case Report with Emphasis on Diagnosis and Treatment. http://www.ejmjih.com/?mno=227949 [Access: February 23, 2018]. doi:10.5455/jihp.20161019105523


AMA (American Medical Association) Style

Hongal B, Joshi PS, Sanadi A. Proliferative Verrucous Leukoplakia: A Case Report with Emphasis on Diagnosis and Treatment. J Interdiscipl Histopathol. 2016; 4(4): 110-113. doi:10.5455/jihp.20161019105523



Vancouver/ICMJE Style

Hongal B, Joshi PS, Sanadi A. Proliferative Verrucous Leukoplakia: A Case Report with Emphasis on Diagnosis and Treatment. J Interdiscipl Histopathol. (2016), [cited February 23, 2018]; 4(4): 110-113. doi:10.5455/jihp.20161019105523



Harvard Style

Hongal, B., Joshi, P. S. & Sanadi, A. (2016) Proliferative Verrucous Leukoplakia: A Case Report with Emphasis on Diagnosis and Treatment. J Interdiscipl Histopathol, 4 (4), 110-113. doi:10.5455/jihp.20161019105523



Turabian Style

Hongal, Bhagyalaxmi, Priya Shirish Joshi, and Appasaheb Sanadi. 2016. Proliferative Verrucous Leukoplakia: A Case Report with Emphasis on Diagnosis and Treatment. Journal of Interdisciplinary Histopathology, 4 (4), 110-113. doi:10.5455/jihp.20161019105523



Chicago Style

Hongal, Bhagyalaxmi, Priya Shirish Joshi, and Appasaheb Sanadi. "Proliferative Verrucous Leukoplakia: A Case Report with Emphasis on Diagnosis and Treatment." Journal of Interdisciplinary Histopathology 4 (2016), 110-113. doi:10.5455/jihp.20161019105523



MLA (The Modern Language Association) Style

Hongal, Bhagyalaxmi, Priya Shirish Joshi, and Appasaheb Sanadi. "Proliferative Verrucous Leukoplakia: A Case Report with Emphasis on Diagnosis and Treatment." Journal of Interdisciplinary Histopathology 4.4 (2016), 110-113. Print. doi:10.5455/jihp.20161019105523



APA (American Psychological Association) Style

Hongal, B., Joshi, P. S. & Sanadi, A. (2016) Proliferative Verrucous Leukoplakia: A Case Report with Emphasis on Diagnosis and Treatment. Journal of Interdisciplinary Histopathology, 4 (4), 110-113. doi:10.5455/jihp.20161019105523





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