E-ISSN 2146-8362
 

Original Research 


Cadmium-Induced Testicular Toxicity, Oxidative Stress and Histopathology in Wistar Rats: Sustained Effects of Polyphenol-Rich Extract of Vernonia Amygdalina (Del.) Leaf

Christian Eseigbe Imafidon, Olatoye Taiwo Risikat, Bamidele Funminiyi Samuel, Ojo Opeyemi Esther, Ademoye Kehinde Aderonke.

Cited by (4)

Abstract
Background: Cadmium (Cd) is a toxic heavy metal of both environmental and occupational concerns. The health impact of ethno-botanical approaches in attempts to ameliorate its deleterious effects in biological systems should be an area of scientific interest since established therapies are often burdened with undesirable side effects. Aim: To determine the effects of polyphenol-rich extract of the leaf of Vernonia amygdalina (PEVA) on Cd-induced testicular toxicity, oxidative stress, and histopathology in Wistar rats. Materials and Methods: A total of twenty five (25) male Wistar rats were divided into five groups as follows: Group 1 (Control) received distilled water (0.2 ml/100 g i.p.) for 5 consecutive days and thereafter left untreated for 28 days. Group 2 received Cd alone at 5 mg/kg (i.p.) for 5 consecutive days. Group 3 was pre-treated with Cd as Group 2 and thereafter left untreated for a period of 28 days, whereas Groups 4 and 5 were pre-treated with Cd as Group 2 and thereafter received PEVA (orally) at two dose levels (200 and 400 mg/kg, respectively) for 28 days. Results: Cd administration induced reproductive toxicity as evidenced by lowered level of follicle stimulating hormone, luteinizing hormone, and testosterone (P < 0.05); perturbation of sperm characterization (P < 0.05); deleterious disruptions of the antioxidant system as evidenced by lowered levels of reduced glutathione and superoxide dismutase as well as elevation in thiobarbituric acid reactive substances level (P < 0.05); decrease in relative testicular weight (P < 0.05); and severe disseminated necrosis of the seminiferous tubules with terminally undifferentiated/necrotic cells as revealed by the histopathological examination. These conditions were sustained following administration of the two dose levels of PEVA. Conclusion: PEVA administration is not a suitable therapeutic choice for fertility enhancement in male Wistar rat model of Cd-induced decline in reproductive function.

Key words: Cadmium, testicular toxicity, rats, polyphenol-rich extract, Vernonia amygdalina.


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Export to
Export to
Related Records
 Articles by Christian Eseigbe Imafidon
Articles by Olatoye Taiwo Risikat
Articles by Bamidele Funminiyi Samuel
Articles by Ojo Opeyemi Esther
Articles by Ademoye Kehinde Aderonke
on Google
on Google Scholar
Article Statistics
 Viewed: 915
Downloaded: 336
Cited: 4

REFERENCES
1. Oura C, Toshimori K. Ultrastructural studies on the fertilization of mammalian gametes. Int Rev Cytol 1990;122:105-51. [DOI via Crossref]   
2. Barltrop D, Khoo HE. The influence of nutritional factors on lead absorption. Postgrad Med J 1975;51:795-800. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
3. Nawal KA, Ula AK, Ban TS. Protective influence of zinc on reproductive parameters in male rat treated with cadmium. Am J Med Med Sci 2015;5:73-81.
4. Imafidon CE, Akomolafe RO, Sanusi AA, Ogundipe OJ, Olukiran OS, Ayowole OA. Polyphenol-rich extract of Vernonia amygdalina (Del.) leaves ameliorated cadmium-induced alterations in feeding pattern and urine volume of male Wistar rats. J Intercult Ethnopharmacol 2015;4:284-92. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
5. IPCS, (International Programme on Chemical Safety). Cadmium - Environmental Aspects. Geneva: World Health Organization; 1992. p. 135.
6. WHO, (World Health Organization). Preventing Disease through Healthy Environments, Exposure to Cadmium: A Major Public Health Concern. Geneva, Switzerland: WHO; 2010.
7. Lewis GP, Coughlin LL, Jusko WJ, Hartz S. Contribution of cigarette smoking to cadmium accumulation in man. Lancet 1972;1:291-2. [DOI via Crossref]   
8. Järup L, Berglund M, Elinder CG, Nordberg G, Vahter M. Health effects of cadmium exposure – a review of the literature and a risk estimate. Scand J Work Environ Health 1998;24 Suppl 1:1-51. [Pubmed]   
9. Bernard A. Renal dysfunction induced by cadmium: Biomarkers of critical effects. Biometals 2004;17:519-23. [DOI via Crossref]    [Pubmed]   
10. Nordberg G, Nogawa K, Nordberg M, Friberg L. Cadmium. In: Handbook on Toxicology of Metals. New York: Academic Press; 2007. p. 65-78. [DOI via Crossref]   
11. Prozialeck WC, Edwards JR, Woods JM. The vascular endothelium as a target of cadmium toxicity. Life Sci 2006;79:1493-506. [DOI via Crossref]    [Pubmed]   
12. Goering PL, Waalkes MP, Klaasen CD. Toxicology of cadmium. Handbook of Experimental Pharmacology; Toxicology of Metals, Biochemical Effects. Vol. 115. New York: Springer-Verlag; 1994. p. 189-214. [PMC Free Fulltext]   
13. Klaassen CD, Liu J, Choudhuri S. Metallothionein: An intracellular protein to protect against cadmium toxicity. Annu Rev Pharmacol Toxicol 1999;39:267-94. [DOI via Crossref]    [Pubmed]   
14. Stohs SJ, Bagchi D, Hassoun E, Bagchi M. Oxidative mechanisms in the toxicity of chromium and cadmium ions. J Environ Pathol Toxicol Oncol 2001;20:77-88. [DOI via Crossref]    [Pubmed]   
15. Nagma M, Nagma JA, Jamal S, Abdur R. Protective effect of rutin against cadmium induced hepatotoxicity in Swiss Albino Mice. J Pharmacol Toxicol 2012;7:150-7. [DOI via Crossref]   
16. Stohs SJ, Bagchi D. Oxidative mechanisms in the toxicity of metal ions. Free Radic Biol Med 1995;18:321-36. [DOI via Crossref]   
17. Buzzle-Side Effects of Polyphenols. August, 24; 2010. Available from: http://www.buzzle.com/articles/polyphenols-side-effects.html. [Last accessed on 2016 Mar 22].
18. Doaa El-Nager M, Badr AA. Effect of corn oil, flax seed oil and black seed oil on testicular damage induced by lead acetate in Albino Mice: A histological study. Pak J Zool 2013;45:1083-9.
19. Dong L, Pauline L, Jeffery CD, Xiu-Fang W, Lubomir P, Paul KW, et al A - tocopheryl succinate induces apoptosis by targeting ubiquinonebinding sites in mitochondrial repiratory mcomplex II. Oncogene 2008;27:4324-35. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
20. Tsao R. Chemistry and biochemistry of dietary polyphenols. Nutrients 2010;2:1231-46. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
21. Schiffers RR. African Indigenous Vegetables: An Overview of the Cultivated Species. England: University Greenwich Press; 2000.
22. Munaya C. 27 Million Nigerians Have Chronic Kidney Disease. News Updates; 2011. Available from: http://www.gbooza.com/group/ medicare/forum/topics/27-million-nigerians-have. [Last accessed on 2015 Oct 13].
23. Louise IM, Ron W, Catherine BP, Augustin S. Risks and safety of polyphenol consumption. Am J Clin Nutr 2005;81:326S-9.
24. Guide for the Care and Use of Laboratory Animals; 2011. 8th ed. Available from: http://www.google.com.ng/?gfe_rd=cr&ei=KWkS Vvy7MtPH8gehuLvQDg#q=nih+guidelines+animal+care. [Last accessed on 2015 Oct 05].
25. Bloom W, Fawcett DW. Male reproductive system. In: Text Book of Histology. Bloom W, editor. 2nd ed. Philadelphia, PA: Saunders Company; 1975.
26. Beutler E, Duron O, Kelly BM. Improved method for the determination of blood glutathione. J Lab Clin Med 1963;61:882-8. [Pubmed]   
27. McCord JM, Fridovich I. Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). J Biol Chem 1969;244:6049-55. [Pubmed]   
28. Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem 1979;95:351-8. [DOI via Crossref]   
29. Perron NR, Brumaghim JL. A review of the antioxidant mechanisms of polyphenol compounds related to iron binding. Cell Biochem Biophys 2009;53:75-100. [DOI via Crossref]    [Pubmed]   
30. Fraga CG, Galleano M, Verstraeten SV, Oteiza PI. Basic biochemical mechanisms behind the health benefits of polyphenols. Mol Aspects Med 2010;31:435-45. [DOI via Crossref]    [Pubmed]   
31. Stuart IF. Human Physiology. 12th ed. New York: McGraw-Hill; 2011.
32. Sembulingam K, Prema S. Essentials of Medical Physiology. 6th ed. New Delhi: Jaypee Brothers Medical Publishers; 2012. [DOI via Crossref]   
33. Lafuente A, Márquez N, Pérez-Lorenzo M, Pazo D, Esquifino AI. Cadmium effects on hypothalamic-pituitary-testicular axis in male rats. Exp Biol Med (Maywood) 2001;226:605-11.
34. Farombi EO, Adedara IA, Akinrinde SA, Ojo OO, Eboh AS. Protective effects of kolaviron and quercetin on cadmium-induced testicular damage and endocrine pathology in rats. Andrologia 2012;44:273-84. [DOI via Crossref]    [Pubmed]   
35. Ballester J, Mu-oz MC, Domínguez J, Rigau T, Guinovart JJ, Rodríguez-Gil JE. Insulin-dependent diabetes affects testicular function by FSH- and LH-linked mechanisms. JAndrol 2004;25:706-19. [DOI via Crossref]   
36. Meistrich ML. Quantitative correlation between testicular stem cell survival, sperm production, and fertility in mouse after treatment with different cytotoxic agents. J Androl 1982;3:58-68. [DOI via Crossref]   
37. Afaf AE. Influence of subchronic exposure of lead on biochemical markers and microelements in testicular tissue of rats. Mars Land Press J Am Toxicol Environ Chem 2009;93:1-22.
38. Egbunike GN, Branscheid W, Pfisterer J, Holtz W. Changes in porcine sperm lactate dehydrogenase isoenzymes during sperm maturation. Andrologia 1986b;18:108-13. [DOI via Crossref]    [Pubmed]   
39. Dua A, Vaidya SR. Sperm motility and morphology as changing parameters linked to sperm count variations. J Postgrad Med 1996;42:93-6. [Pubmed]   
40. Fosterb P. Principles for Evaluating Health Risks to Reproduction Associated with Exposure to Chemicals. World Health Organization; 2001. Available from: https://www.books.google. com.ng/books?id= v4qW4XgXXrcC&pg= PA62&lpg= PA62&dq= ~Morrissey+1989+%2B+US+EPA+1998&source= bl&ots= V7iABkntTy&sig= DLx35v9VDuPKDWbb82d6Z-971nc&hl= en&sa= X&ved= 0ahUKEwjvktD-4OHJAhXBPhQKHQP4Ak8Q6AEIHjAA#v= onepage&q= ~Morrissey%201989%20%2B%20US%20EPA%20 1998&f= false. [Last accessed on 2015 Oct 11].
41. Ramesh CG. Reproductive and Developmental Toxicology. Academic Press; 2011. Available from: https://www.books.google.com. ng/books?id= jGHRR32wz5MC&pg= PA116&lpg= PA116&dq= ~Morrissey+1989+%2B+US+EPA+1998&source= bl&ots= xx45-rvQnv&sig= fD9cE4i9C5ZujIFNj1h4I3xElZs&hl= en&sa= X&ved= 0ahUKEwjvktD-4OHJAhXBPhQKHQP4Ak8Q6AEIPDAI#v= onepage&q= ~Morrissey%201989%20%2B%20US%20EPA%20 998&f= false. [Last accessed on 2015 Oct 11].
42. Chapin RE, Davis MW, Ward BJ, Wilson SM, Mauney RE,Lockhart MA, et al The effects of perinatal/juvenile methoxychlor exposure on adult rat nervous, immune, and reproductive system function. Toxicol Sci 2007;10:1371-4.
43. Mooradian AD, Morley JE, Korenman SG. Biological actions of androgens. Endocr Rev 1987;8:1-28. [DOI via Crossref]    [Pubmed]   
44. Imafidon CE, Akomolafe RO, Abubakar SA, Ogundipe OJ, Olukiran OS, Ayowole OA. Amelioration of cadmium-induced nephropathy using polyphenol-rich extract of Vernonia amygdalina (Del.) leaves in rat model. Open Access Maced J Med Sci 2015;3:567-77. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
45. Katherine AS, Niamh MM, Steve RB. Hypothalamic regulation of apetite. Exp Rev Endocrinol Metab 2008;3:577-92. [DOI via Crossref]   
46. Halliwell B, Gutteridge JM, Cross CE. Free radicals, antioxidants, and human disease: Where are we now? J Lab Clin Med 1992;119:598-620. [Pubmed]   
47. Khan RA. Protective effects of Launaea procumbens on rat testis damage by CCl4. Lipids Health Dis 2012;11:103. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
48. Thangarajan S, Chandrasekar S, Varadharajan M, Sureka M, Subathra M, Vishali A, et al Oxidative stress in brains of male rats intoxicated with aluminium and neuromodulating effect of celastrus paniculatus alcoholic seed extract. Asian J Pharm Clin Res 2013;6:80-90.
49. Kurata M, Suzuki M, Agar NS. Antioxidant systems and erythrocyte life-span in mammals. Comp Biochem Physiol B 1993;106:477-87. [DOI via Crossref]   

This Article Cited By the following articles

Acetonic extract of Vernonia amygdalina (Del.) attenuates Cd-induced liver injury: Potential application in adjuvant heavy metal therapy
Toxicology Reports 2018; 5(): 324.

1
 
Ginger polyphenols attenuate cyclosporine-induced disturbances in kidney function: Potential application in adjuvant transplant therapy
Pathophysiology 2018; (): .

2
 
Sub-acute administration of lower doses of nicotine caused sex-dependent improvement of renal function in Wistar rats
Toxicology Reports 2017; (): .

3
 
Neuro-endocrine effects of aqueous extract of Amaranthus viridis (Linn.) leaf in male Wistar rat model of cyclophosphamide-induced reproductive toxicity
Toxicology Reports 2016; 3(): 608.

4
 

How to Cite this Article
Pubmed Style

Imafidon CE, Risikat OT, Samuel BF, Esther OO, Aderonke AK. Cadmium-Induced Testicular Toxicity, Oxidative Stress and Histopathology in Wistar Rats: Sustained Effects of Polyphenol-Rich Extract of Vernonia Amygdalina (Del.) Leaf. J Interdiscip Histopathol. 2016; 4(3): 54-62. doi:10.5455/jihp.20160618041629


Web Style

Imafidon CE, Risikat OT, Samuel BF, Esther OO, Aderonke AK. Cadmium-Induced Testicular Toxicity, Oxidative Stress and Histopathology in Wistar Rats: Sustained Effects of Polyphenol-Rich Extract of Vernonia Amygdalina (Del.) Leaf. http://www.ejmjih.com/?mno=226859 [Access: August 16, 2018]. doi:10.5455/jihp.20160618041629


AMA (American Medical Association) Style

Imafidon CE, Risikat OT, Samuel BF, Esther OO, Aderonke AK. Cadmium-Induced Testicular Toxicity, Oxidative Stress and Histopathology in Wistar Rats: Sustained Effects of Polyphenol-Rich Extract of Vernonia Amygdalina (Del.) Leaf. J Interdiscip Histopathol. 2016; 4(3): 54-62. doi:10.5455/jihp.20160618041629



Vancouver/ICMJE Style

Imafidon CE, Risikat OT, Samuel BF, Esther OO, Aderonke AK. Cadmium-Induced Testicular Toxicity, Oxidative Stress and Histopathology in Wistar Rats: Sustained Effects of Polyphenol-Rich Extract of Vernonia Amygdalina (Del.) Leaf. J Interdiscip Histopathol. (2016), [cited August 16, 2018]; 4(3): 54-62. doi:10.5455/jihp.20160618041629



Harvard Style

Imafidon, C. E., Risikat, O. T., Samuel, B. F., Esther, O. O. & Aderonke, A. K. (2016) Cadmium-Induced Testicular Toxicity, Oxidative Stress and Histopathology in Wistar Rats: Sustained Effects of Polyphenol-Rich Extract of Vernonia Amygdalina (Del.) Leaf. J Interdiscip Histopathol, 4 (3), 54-62. doi:10.5455/jihp.20160618041629



Turabian Style

Imafidon, Christian Eseigbe, Olatoye Taiwo Risikat, Bamidele Funminiyi Samuel, Ojo Opeyemi Esther, and Ademoye Kehinde Aderonke. 2016. Cadmium-Induced Testicular Toxicity, Oxidative Stress and Histopathology in Wistar Rats: Sustained Effects of Polyphenol-Rich Extract of Vernonia Amygdalina (Del.) Leaf. Journal of Interdisciplinary Histopathology, 4 (3), 54-62. doi:10.5455/jihp.20160618041629



Chicago Style

Imafidon, Christian Eseigbe, Olatoye Taiwo Risikat, Bamidele Funminiyi Samuel, Ojo Opeyemi Esther, and Ademoye Kehinde Aderonke. "Cadmium-Induced Testicular Toxicity, Oxidative Stress and Histopathology in Wistar Rats: Sustained Effects of Polyphenol-Rich Extract of Vernonia Amygdalina (Del.) Leaf." Journal of Interdisciplinary Histopathology 4 (2016), 54-62. doi:10.5455/jihp.20160618041629



MLA (The Modern Language Association) Style

Imafidon, Christian Eseigbe, Olatoye Taiwo Risikat, Bamidele Funminiyi Samuel, Ojo Opeyemi Esther, and Ademoye Kehinde Aderonke. "Cadmium-Induced Testicular Toxicity, Oxidative Stress and Histopathology in Wistar Rats: Sustained Effects of Polyphenol-Rich Extract of Vernonia Amygdalina (Del.) Leaf." Journal of Interdisciplinary Histopathology 4.3 (2016), 54-62. Print. doi:10.5455/jihp.20160618041629



APA (American Psychological Association) Style

Imafidon, C. E., Risikat, O. T., Samuel, B. F., Esther, O. O. & Aderonke, A. K. (2016) Cadmium-Induced Testicular Toxicity, Oxidative Stress and Histopathology in Wistar Rats: Sustained Effects of Polyphenol-Rich Extract of Vernonia Amygdalina (Del.) Leaf. Journal of Interdisciplinary Histopathology, 4 (3), 54-62. doi:10.5455/jihp.20160618041629





Most Viewed Articles
  • Prevalence of Anemia and Associated Risk Factors among Pregnant Women Attending Antenatal Care in Azezo Health Center Gondar Town, Northwest Ethiopia
    Meseret Alem, Bamlaku Enawgaw, Aschalew Gelaw, Tigist Kenaw, Mohamed Seid , Yadesa Olkeba
    J Interdiscip Histopathol. 2013; 1(3): 137-144
    » Abstract & References » doi: 10.5455/jihp.20130122042052

  • Cytomorphometric Analysis of Oral Premalignant and Malignant Lesions Using Feulgen Stain and Exfoliative Brush Cytology.
    Priya Shirish Joshi, Manasi Sandipak Kaijkar
    J Interdiscip Histopathol. 2013; 1(4): 204-211
    » Abstract & References » doi: 10.5455/jihp.20130214064844

  • Differences in the Angiogenesis of Benign and Malignant Surface Epithelial Ovarian Tumors Demonstrated by Microvessel Density and Immunohistochemistry
    Shelly Sehgal, Prashant Goyal, Reena Agarwal, Sompal Singh, Awanindra Kumar, Ruchika Gupta, Vinita Kumar, Dipti Agrawal
    J Interdiscip Histopathol. 2013; 1(3): 145-152
    » Abstract & References » doi: 10.5455/jihp.20130204114930

  • The Role of CD10 Immunohistochemistry in the Grading of Phyllodes Tumour of The Breast
    Huzlinda Hussin,Jayalakshmi Pailoor, Peh Suat Cheng
    J Interdiscip Histopathol. 2013; 1(4): 195-203
    » Abstract & References » doi: 10.5455/jihp.20130307011432

  • Retroperitoneal Non-functioning Paraganglioma: A Case Report
    Faten Limaiem, Saadia Bouraoui, Sirine Bouslama, Sana Ben Slama, Ahlem Lahmar, Sabeh Mzabi-Regaya
    J Interdiscip Histopathol. 2013; 1(3): 168-171
    » Abstract & References » doi: 10.5455/jihp.20130115114630

  • P53 Immunohistochemical Staining Patterns in Benign, Premalignant and Malignant Lesions of the Oral Cavity: A Study of 68 Cases
    Pankaj Baweja, Vidya Monappa, Geetha Krishnanand
    J Interdiscip Histopathol. 2013; 1(3): 113-120
    » Abstract & References » doi: 10.5455/jihp.20130121120725

  • Nonspecific Cecal Ulcer: An Obsolete Jargon
    Duvuru Ram, Vilvapathy Senguttuvan Karthikeyan, Sarath Chandra Sistla
    J Interdiscip Histopathol. 2013; 1(2): 85-88
    » Abstract & References » doi: 10.5455/jihp.20121228043742

  • Histopathology as diagnostic tool for Ascosphaera apis infection in apparently healthy honey bees (Apis mellifera ligustica)
    Paola Maiolino, Francesca Carella, Giovanna De Leva, Laura Rinaldi, Giuseppe Cringoli, Manuela Martano
    J Interdiscip Histopathol. 2013; 1(3): 160-162
    » Abstract & References » doi: 10.5455/jihp.20130128010436

  • Double-Hit Lymphoma Presenting as Primary Renal Lymphoma: A Case Report
    Vikas Mehta, Chad Ellimottil, Jodi Speiser, Milind Velankar, Guliz A Barkan
    J Interdiscip Histopathol. 2013; 1(2): 93-97
    » Abstract & References » doi: 10.5455/jihp.20130121075815

  • Lateral Periodontal Cyst: A Report of Two Cases with Varying Clinico-Radiological Features
    Preethi Balan, Subhas G Babu, Shishir Shetty, Deepa Dsouza
    J Interdiscip Histopathol. 2012; 1(1): 41-44
    » Abstract & References » doi: 10.5455/jihp.20120808010902

  • Most Downloaded
  • Prevalence of Anemia and Associated Risk Factors among Pregnant Women Attending Antenatal Care in Azezo Health Center Gondar Town, Northwest Ethiopia
    Meseret Alem, Bamlaku Enawgaw, Aschalew Gelaw, Tigist Kenaw, Mohamed Seid , Yadesa Olkeba
    J Interdiscip Histopathol. 2013; 1(3): 137-144
    » Abstract & References » doi: 10.5455/jihp.20130122042052

  • Cytomorphometric Analysis of Oral Premalignant and Malignant Lesions Using Feulgen Stain and Exfoliative Brush Cytology.
    Priya Shirish Joshi, Manasi Sandipak Kaijkar
    J Interdiscip Histopathol. 2013; 1(4): 204-211
    » Abstract & References » doi: 10.5455/jihp.20130214064844

  • P53 Immunohistochemical Staining Patterns in Benign, Premalignant and Malignant Lesions of the Oral Cavity: A Study of 68 Cases
    Pankaj Baweja, Vidya Monappa, Geetha Krishnanand
    J Interdiscip Histopathol. 2013; 1(3): 113-120
    » Abstract & References » doi: 10.5455/jihp.20130121120725

  • Small Cell Lung Carcinoma: Better Than Its Reputation? A Population Based Study
    Hans Rostad, Erik Heyerdahl Strom, Helge Scott, Maria Ramnefjell, Kjell Kjellevold
    J Interdiscip Histopathol. 2012; 1(1): 1-4
    » Abstract & References » doi: 10.5455/jihp.20120703032839

  • Stented Vessels: A Challenge for Histological Preparation and Microscopy
    Andrea Nolte, Theresa Braun, Sven Zur Oven Krockhaus, Adelheid Munz, Ulrich Vogel, Christian Schlensak, Hans Wendel, Tobias Walker
    J Interdiscip Histopathol. 2013; 1(3): 104-112
    » Abstract & References » doi: 10.5455/jihp.20130306112937

  • Histopathology of the Liver Following Administration of Artesunate in Adult Wistar Rats
    Felix Monday Onyije, Josiah S Hart
    J Interdiscip Histopathol. 2012; 1(1): 26-29
    » Abstract & References » doi: 10.5455/jihp.20120606081137

  • Role of HPV Vaccine in the Prevention of Cervical Cancer
    Saleh JA, Yusuph H, Zailani ZB
    J Interdiscip Histopathol. 2013; 1(4): 212-216
    » Abstract & References » doi: 10.5455/jihp.20130119122700

  • Lateral Periodontal Cyst: A Report of Two Cases with Varying Clinico-Radiological Features
    Preethi Balan, Subhas G Babu, Shishir Shetty, Deepa Dsouza
    J Interdiscip Histopathol. 2012; 1(1): 41-44
    » Abstract & References » doi: 10.5455/jihp.20120808010902

  • Histopathological Effects of Varied Fluoride Concentration on Cerebrum in Albino Rats
    Sajad Hamid, Zaffar Kawoosa, Shahnawaz Hamid, M.A. Mir, Athar Hafiz, Irfan Jan, Fayiza Yaqoob
    J Interdiscip Histopathol. 2012; 1(1): 30-34
    » Abstract & References » doi: 10.5455/jihp.20121105123701

  • The Role of CD10 Immunohistochemistry in the Grading of Phyllodes Tumour of The Breast
    Huzlinda Hussin,Jayalakshmi Pailoor, Peh Suat Cheng
    J Interdiscip Histopathol. 2013; 1(4): 195-203
    » Abstract & References » doi: 10.5455/jihp.20130307011432

  • Most Cited Articles
  • Prevalence of Anemia and Associated Risk Factors among Pregnant Women Attending Antenatal Care in Azezo Health Center Gondar Town, Northwest Ethiopia
    Meseret Alem, Bamlaku Enawgaw, Aschalew Gelaw, Tigist Kenaw, Mohamed Seid , Yadesa Olkeba
    J Interdiscip Histopathol. 2013; 1(3): 137-144
    » Abstract & References » doi: 10.5455/jihp.20130122042052
    Cited : 19 times [Click to see citing articles]

  • Renal Biopsy for Research: An Overview of Russian Experience
    Sergei V. Jargin
    J Interdiscip Histopathol. 2014; 2(2): 88-95
    » Abstract & References » doi: 10.5455/jihp.20140312020838
    Cited : 4 times [Click to see citing articles]

  • Cadmium-Induced Testicular Toxicity, Oxidative Stress and Histopathology in Wistar Rats: Sustained Effects of Polyphenol-Rich Extract of Vernonia Amygdalina (Del.) Leaf
    Christian Eseigbe Imafidon, Olatoye Taiwo Risikat, Bamidele Funminiyi Samuel, Ojo Opeyemi Esther, Ademoye Kehinde Aderonke
    J Interdiscip Histopathol. 2016; 4(3): 54-62
    » Abstract & References » doi: 10.5455/jihp.20160618041629
    Cited : 4 times [Click to see citing articles]

  • Characterization of the Blood Brain Barrier in Pediatric Central Nervous System Neoplasms
    Christopher S Hong, Winson Ho, Martin G Piazza, Abhik Ray-Chaudhury, Zhengping Zhuang, John D Heiss
    J Interdiscip Histopathol. 2016; 4(2): 29-33
    » Abstract & References » doi: 10.5455/jihp.20160623053540
    Cited : 4 times [Click to see citing articles]

  • The Senescence Process of Internal Thoracic Artery
    Antonio Manenti, Luca Roncati, Giuseppe Barbolini, Francesco Rivasi
    J Interdiscip Histopathol. 2013; 1(2): 58-61
    » Abstract & References » doi: 10.5455/jihp.20121211115233
    Cited : 3 times [Click to see citing articles]

  • Primary Biliary Cirrhosis Overlapping with Autoimmune Hepatitis in an HIV-Infected Patient on Antiretroviral Therapy
    Margaret Rae Caplan, Apurva Trivedi, Mary McLaughlin, Annick Hebou, David Kleiner, Theo Heller, Caryn Morse
    J Interdiscip Histopathol. 2013; 1(5): 270-273
    » Abstract & References » doi: 10.5455/jihp.20130624104921
    Cited : 3 times [Click to see citing articles]

  • Evaluation of Amelotin Expression in Benign Odontogenic Tumors
    Daiana Paula Stolf, Tae-Young Lee, Grace Bradley, Bernhard Ganss
    J Interdiscip Histopathol. 2013; 1(5): 236-245
    » Abstract & References » doi: 10.5455/jihp.20130506045106
    Cited : 2 times [Click to see citing articles]

  • Diffuse Cutaneous Leishmaniasis in an HIV Sero-Positive Patient - A Diagnostic Dilemma
    Kumar U Mahesh, Balasaheb Ramling Yelikar, Ratnakar Madhav Rao Potekar, Palin Aparna, Murthy Keshav
    J Interdiscip Histopathol. 2012; 1(1): 45-47
    » Abstract & References » doi: 10.5455/jihp.20121109060828
    Cited : 2 times [Click to see citing articles]

  • Small Cell Lung Carcinoma: Better Than Its Reputation? A Population Based Study
    Hans Rostad, Erik Heyerdahl Strom, Helge Scott, Maria Ramnefjell, Kjell Kjellevold
    J Interdiscip Histopathol. 2012; 1(1): 1-4
    » Abstract & References » doi: 10.5455/jihp.20120703032839
    Cited : 2 times [Click to see citing articles]

  • Association of Claudin-1 with E-Cadherin/Catenin Complex, Microvessel Density (MVD)-Related Markers, and Clinicopathological Features in Colorectal Carcinoma
    Urania Skoufi, Dimitrios L Arvanitis, Litsa Lampri, Elli Ioachim, Jim Koutsogiannis, Christina Skoufi, Dimitris Tsironis and Antigony Mitselou
    J Interdiscip Histopathol. 2014; 2(3): 135-144
    » Abstract & References » doi: 10.5455/jihp.20140429121735
    Cited : 2 times [Click to see citing articles]