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Immunohistochemical Study of Prognostic Relevance of Nestin and Survivin Expression in Astrocytic glioma

Aziza E. Abdelrahman, Hesham R. Abdel-Aziz, Abdelmonem A. Hegazy, Abdel-Motaleb Mohamed.

Cited by (1)

Abstract
Background: Identification of the cellular origin of astrocytic gliomas is a step for improving the treatment strategies. Tumor stem cells have been detected in different neoplasms and have a major role in tumor initiation, progression and therapy resistance.
Objective: The study aimed to investigate the expression of nestin and survivin in different grades of astrocytic glioma as well as evaluation of their prognostic role in relation to other prognostic parameters.
Methods: Immunohistochemical expressions of nestin and survivin were evaluated in 40 paraffin blocks of different grades of astrocytic glioma and correlated with other prognostic parameters. The obtained data were statistically analyzed.
Results: The cases included 10 low grade, 12 anaplastic and 18 glioblastoma multiforme. There was a significant correlation between each of nestin and survivin with the histological grade of astrocytoma and tumor size (p < 0.001). Nestin was strongly correlated to survivin index (p < 0.001). The univariate analysis showed that high histological grade, high nestin score and high survivin index were significantly correlated with overall survival. Multivariate analysis for all investigated cases proved the independent prognostic significance of the nestin expression (p = 0.011).
Conclusion: Nestin and survivin are adverse prognostic markers for astrocytic glioma that increase significantly with tumor progression and associated with poor overall survival. Therefore, nestin and survivin could be used to predict high risk group of astrocytoma with unfavorable outcome.

Key words: Astrocytoma, Nestin, Survivin, Immunohistochemistry, Prognosis


 
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How to Cite this Article
Pubmed Style

Abdelrahman AE, Abdel-Aziz HR, Hegazy AA, Mohamed A. Immunohistochemical Study of Prognostic Relevance of Nestin and Survivin Expression in Astrocytic glioma. J Interdiscip Histopathol. 2016; 4(2): 34-40. doi:10.5455/jihp.20160420021353


Web Style

Abdelrahman AE, Abdel-Aziz HR, Hegazy AA, Mohamed A. Immunohistochemical Study of Prognostic Relevance of Nestin and Survivin Expression in Astrocytic glioma. http://www.ejmjih.com/?mno=222145 [Access: October 18, 2018]. doi:10.5455/jihp.20160420021353


AMA (American Medical Association) Style

Abdelrahman AE, Abdel-Aziz HR, Hegazy AA, Mohamed A. Immunohistochemical Study of Prognostic Relevance of Nestin and Survivin Expression in Astrocytic glioma. J Interdiscip Histopathol. 2016; 4(2): 34-40. doi:10.5455/jihp.20160420021353



Vancouver/ICMJE Style

Abdelrahman AE, Abdel-Aziz HR, Hegazy AA, Mohamed A. Immunohistochemical Study of Prognostic Relevance of Nestin and Survivin Expression in Astrocytic glioma. J Interdiscip Histopathol. (2016), [cited October 18, 2018]; 4(2): 34-40. doi:10.5455/jihp.20160420021353



Harvard Style

Abdelrahman, A. E., Abdel-Aziz, H. R., Hegazy, A. A. & Mohamed, A. (2016) Immunohistochemical Study of Prognostic Relevance of Nestin and Survivin Expression in Astrocytic glioma. J Interdiscip Histopathol, 4 (2), 34-40. doi:10.5455/jihp.20160420021353



Turabian Style

Abdelrahman, Aziza E., Hesham R. Abdel-Aziz, Abdelmonem A. Hegazy, and Abdel-Motaleb Mohamed. 2016. Immunohistochemical Study of Prognostic Relevance of Nestin and Survivin Expression in Astrocytic glioma. Journal of Interdisciplinary Histopathology, 4 (2), 34-40. doi:10.5455/jihp.20160420021353



Chicago Style

Abdelrahman, Aziza E., Hesham R. Abdel-Aziz, Abdelmonem A. Hegazy, and Abdel-Motaleb Mohamed. "Immunohistochemical Study of Prognostic Relevance of Nestin and Survivin Expression in Astrocytic glioma." Journal of Interdisciplinary Histopathology 4 (2016), 34-40. doi:10.5455/jihp.20160420021353



MLA (The Modern Language Association) Style

Abdelrahman, Aziza E., Hesham R. Abdel-Aziz, Abdelmonem A. Hegazy, and Abdel-Motaleb Mohamed. "Immunohistochemical Study of Prognostic Relevance of Nestin and Survivin Expression in Astrocytic glioma." Journal of Interdisciplinary Histopathology 4.2 (2016), 34-40. Print. doi:10.5455/jihp.20160420021353



APA (American Psychological Association) Style

Abdelrahman, A. E., Abdel-Aziz, H. R., Hegazy, A. A. & Mohamed, A. (2016) Immunohistochemical Study of Prognostic Relevance of Nestin and Survivin Expression in Astrocytic glioma. Journal of Interdisciplinary Histopathology, 4 (2), 34-40. doi:10.5455/jihp.20160420021353





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