E-ISSN 2146-8362
 

Original Research 


Testicular Toxicity and Sperm Quality Following Exposure to Solignum®: A Permethrin-Containing Wood Preservative in Adult Male Wistar Rats

Kingsley Chukwuemeka Patrick-Iwuanyanwu, Nnaemeka Arinze Udowelle, Chioma Joy Okereke.

Abstract
Background: Permethrin is widely used as a pesticide in agriculture, homes, gardens, and for treatment of ectoparasites such as fleas, lice, and scabies on human and animals. The aim of the present study was to evaluate the testicular toxicity and sperm quality of adult male Wistar albino rats exposed to Solignum® (SOL), a commercial permethrin-containing wood preservative. Materials and Methods: A total number of 32 adult male Wistar albino rats were divided into four groups of eight rats per group. SOL mixed with olive oil (1:1) was orally administered to rats daily at concentrations of 100, 200, and 400 mg/kg for 28 days while the control received 1 ml of olive oil only. At the end of this study, animals were sacrificed and testes excised, weighed, and processed for histological examination. Results: Rats treated with SOL showed a significant (P ≤ 0.05) decrease in body weight ranging from 127.30 ± 5.95 to 84.50 ± 15.37 g as compared with control group (138.50 ± 6.7 g). Absolute testicular weight, relative testicular weight, and epididymis together with testes decreased significantly (P ≤ 0.05) in treated rats ranging from 0.63 ± 0.44 to 0.22 ± 0.18; 0.49 ± 7.39 to 0.26 ± 1.17, and 1.07 ± 0.75 to 0.37 ± 0.19, respectively, when compared with control groups (0.89 ± 0.27; 0.64 ± 4.00; and 1.40 ± 0.35) for absolute testicular weight, relative testicular weight, and epididymis together with testes, respectively after 28 days. However, there was a significant (P ≤ 0.05) decrease in sperm count, sperm motility, sperm morphology, and sperm viability, whereas sperm debris increased significantly (P ≤ 0.05) in a dose-dependent manner when compared with control group. Furthermore, histological examination of the testes indicated that rats exposed to SOL were characterized by significant degenerative changes when compared with control group. Conclusion: Therefore, exposure to SOL may inhibit spermatogenesis, impair fertility, and generally, have toxicological concerns in the male reproductive system.

Key words: Testicular toxicity, wood preservative, permethrin, public health, infertility, Solignum®


 
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How to Cite this Article
Pubmed Style

Patrick-Iwuanyanwu KC, Udowelle NA, Okereke CJ. Testicular Toxicity and Sperm Quality Following Exposure to Solignum®: A Permethrin-Containing Wood Preservative in Adult Male Wistar Rats. J Interdiscip Histopathol. 2016; 4(1): 13-16. doi:10.5455/jihp.20151125081952


Web Style

Patrick-Iwuanyanwu KC, Udowelle NA, Okereke CJ. Testicular Toxicity and Sperm Quality Following Exposure to Solignum®: A Permethrin-Containing Wood Preservative in Adult Male Wistar Rats. http://www.ejmjih.com/?mno=201909 [Access: May 25, 2018]. doi:10.5455/jihp.20151125081952


AMA (American Medical Association) Style

Patrick-Iwuanyanwu KC, Udowelle NA, Okereke CJ. Testicular Toxicity and Sperm Quality Following Exposure to Solignum®: A Permethrin-Containing Wood Preservative in Adult Male Wistar Rats. J Interdiscip Histopathol. 2016; 4(1): 13-16. doi:10.5455/jihp.20151125081952



Vancouver/ICMJE Style

Patrick-Iwuanyanwu KC, Udowelle NA, Okereke CJ. Testicular Toxicity and Sperm Quality Following Exposure to Solignum®: A Permethrin-Containing Wood Preservative in Adult Male Wistar Rats. J Interdiscip Histopathol. (2016), [cited May 25, 2018]; 4(1): 13-16. doi:10.5455/jihp.20151125081952



Harvard Style

Patrick-Iwuanyanwu, K. C., Udowelle, N. A. & Okereke, C. J. (2016) Testicular Toxicity and Sperm Quality Following Exposure to Solignum®: A Permethrin-Containing Wood Preservative in Adult Male Wistar Rats. J Interdiscip Histopathol, 4 (1), 13-16. doi:10.5455/jihp.20151125081952



Turabian Style

Patrick-Iwuanyanwu, Kingsley Chukwuemeka, Nnaemeka Arinze Udowelle, and Chioma Joy Okereke. 2016. Testicular Toxicity and Sperm Quality Following Exposure to Solignum®: A Permethrin-Containing Wood Preservative in Adult Male Wistar Rats. Journal of Interdisciplinary Histopathology, 4 (1), 13-16. doi:10.5455/jihp.20151125081952



Chicago Style

Patrick-Iwuanyanwu, Kingsley Chukwuemeka, Nnaemeka Arinze Udowelle, and Chioma Joy Okereke. "Testicular Toxicity and Sperm Quality Following Exposure to Solignum®: A Permethrin-Containing Wood Preservative in Adult Male Wistar Rats." Journal of Interdisciplinary Histopathology 4 (2016), 13-16. doi:10.5455/jihp.20151125081952



MLA (The Modern Language Association) Style

Patrick-Iwuanyanwu, Kingsley Chukwuemeka, Nnaemeka Arinze Udowelle, and Chioma Joy Okereke. "Testicular Toxicity and Sperm Quality Following Exposure to Solignum®: A Permethrin-Containing Wood Preservative in Adult Male Wistar Rats." Journal of Interdisciplinary Histopathology 4.1 (2016), 13-16. Print. doi:10.5455/jihp.20151125081952



APA (American Psychological Association) Style

Patrick-Iwuanyanwu, K. C., Udowelle, N. A. & Okereke, C. J. (2016) Testicular Toxicity and Sperm Quality Following Exposure to Solignum®: A Permethrin-Containing Wood Preservative in Adult Male Wistar Rats. Journal of Interdisciplinary Histopathology, 4 (1), 13-16. doi:10.5455/jihp.20151125081952





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