E-ISSN 2146-8362
 

Review Article 


Immunoprofiles of Adult Renal Epithelial Tumors: Immunohistochemistry Is Still Essential for Diagnosis of Renal Tumors (A Comprehensive Update)

Ayhan Ozcan.

Abstract
Renal cell carcinoma (RCC) is the third most common cancer of the genitourinary tract and accounts for approximately 2-3% of all cancer deaths. The recent classification of renal tumors, The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia, has been proposed new distinct epithelial tumors and provisional new entities. Although most renal tumors are morphologically diagnosed, they need to use a panel of immunomarkers due to their overlapping morphologic features in some cases such as benign mimickers and newly emerged tumor types. Overlapping morphologic features are especially complicated in small biopsies and in distinguishing metastatic RCCs from other tumors. Immunohistochemistry is still more useful in renal tumors than non-renal tumors. A wide panel has been performed in the differential diagnosis of renal tumors. If immunohistochemical results are conflict or unconvincing, a diagnosis of unclassified RCC is appropriate. For accurate diagnosis of RCC, it should be careful in performing immunohistochemistry on needle biopsy due to variable expressions of immunomarkers originated from heterogeneity in RCCs. Morphology is still gold standard, but immunohistochemistry should be kept in mind as a useful and supportive diagnostic tool upon morphological features of renal tumors as always.

Key words: Immunohistochemistry, kidney, neoplasm, differential diagnosis, diagnostic markers


 
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How to Cite this Article
Pubmed Style

Ayhan Ozcan. Immunoprofiles of Adult Renal Epithelial Tumors: Immunohistochemistry Is Still Essential for Diagnosis of Renal Tumors (A Comprehensive Update). J Interdiscip Histopathol. 2015; 3(3): 81-101. doi:10.5455/jihp.20150930030440


Web Style

Ayhan Ozcan. Immunoprofiles of Adult Renal Epithelial Tumors: Immunohistochemistry Is Still Essential for Diagnosis of Renal Tumors (A Comprehensive Update). http://www.ejmjih.com/?mno=201771 [Access: May 25, 2018]. doi:10.5455/jihp.20150930030440


AMA (American Medical Association) Style

Ayhan Ozcan. Immunoprofiles of Adult Renal Epithelial Tumors: Immunohistochemistry Is Still Essential for Diagnosis of Renal Tumors (A Comprehensive Update). J Interdiscip Histopathol. 2015; 3(3): 81-101. doi:10.5455/jihp.20150930030440



Vancouver/ICMJE Style

Ayhan Ozcan. Immunoprofiles of Adult Renal Epithelial Tumors: Immunohistochemistry Is Still Essential for Diagnosis of Renal Tumors (A Comprehensive Update). J Interdiscip Histopathol. (2015), [cited May 25, 2018]; 3(3): 81-101. doi:10.5455/jihp.20150930030440



Harvard Style

Ayhan Ozcan (2015) Immunoprofiles of Adult Renal Epithelial Tumors: Immunohistochemistry Is Still Essential for Diagnosis of Renal Tumors (A Comprehensive Update). J Interdiscip Histopathol, 3 (3), 81-101. doi:10.5455/jihp.20150930030440



Turabian Style

Ayhan Ozcan. 2015. Immunoprofiles of Adult Renal Epithelial Tumors: Immunohistochemistry Is Still Essential for Diagnosis of Renal Tumors (A Comprehensive Update). Journal of Interdisciplinary Histopathology, 3 (3), 81-101. doi:10.5455/jihp.20150930030440



Chicago Style

Ayhan Ozcan. "Immunoprofiles of Adult Renal Epithelial Tumors: Immunohistochemistry Is Still Essential for Diagnosis of Renal Tumors (A Comprehensive Update)." Journal of Interdisciplinary Histopathology 3 (2015), 81-101. doi:10.5455/jihp.20150930030440



MLA (The Modern Language Association) Style

Ayhan Ozcan. "Immunoprofiles of Adult Renal Epithelial Tumors: Immunohistochemistry Is Still Essential for Diagnosis of Renal Tumors (A Comprehensive Update)." Journal of Interdisciplinary Histopathology 3.3 (2015), 81-101. Print. doi:10.5455/jihp.20150930030440



APA (American Psychological Association) Style

Ayhan Ozcan (2015) Immunoprofiles of Adult Renal Epithelial Tumors: Immunohistochemistry Is Still Essential for Diagnosis of Renal Tumors (A Comprehensive Update). Journal of Interdisciplinary Histopathology, 3 (3), 81-101. doi:10.5455/jihp.20150930030440





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