Required files to uploaded
Author Agreement Form
|Case Report|| |
Appendiceal Hyperplastic Polyp: Case Report
Faten Limaiem, Saadia Bouraoui, Maroua Bouahmed, Ghada Sahraoui, Ahlem Lahmar, Sabeh Mzabi-Regaya.
|Cited by (2)|
Serrated lesions morphologically analogous to those seen in the colorectum are found in the appendix. Appendiceal hyperplastic polyps are very rare, and their true incidence is unknown. A 52-year-old male previously healthy patient with no particular past medical history, presented with a 24-h history of abdominal pain localized to the right lower quadrant. On physical examination, he was tender to palpation in the lower right quadrant. As acute appendicitis was highly suspected, laparoscopic appendectomy was performed. Histological examination of the surgical specimen showed acute inflammation of the appendiceal wall. The crypts were focally elongated but relatively straight with serrations that were visible mainly near the luminal end of the crypts. Columnar cells with or without apical mucous vacuoles alternated with large goblet cells. The crypt bases were not serrated and were lined by regular cells with small nuclei. The muscularis mucosa was intact. The postoperative course was uneventful, and the patient was discharged on postoperative day 1. The final pathological diagnosis was acute appendicitis associated with hyperplastic polyp. Hyperplastic lesions of the appendix are often incidental findings although they can be associated with acute appendicitis. They are significantly associated with adenocarcinoma elsewhere in the large intestine and the finding of mucosal hyperplasia in an appendectomy is an indication for further investigations to exclude colorectal neoplasia.
Appendix, appendicitis, hyperplastic polyp, histopathology
|1. Williams GR, du Boulay CE, Roche WR. Benign epithelial neoplasms of the appendix: Classification and clinical associations. Histopathology 1992;21:447-51. [DOI via Crossref] [Pubmed] |
|2. Rubio CA. Serrated adenomas of the appendix. J Clin Pathol 2004;57:946-9. [DOI via Crossref] [Pubmed] [PMC Free Fulltext] |
|3. Misdraji J. Epithelial neoplasms and other epithelial lesions of the appendix. Curr Diagn Pathol 2005;11:60-71. [DOI via Crossref] |
|4. Carr NJ, Sobin LH. Unusual tumors of the appendix and pseudomyxoma peritonei. Semin Diagn Pathol 1996;13:314-25.|
|5. Appelman HD. Epithelial neoplasia of the appendix. In: Norris HT, editor. Pathology of the Colon, Small Intestine, and Anus. New York: Churchill Livingstone; 1991. p. 263-303.|
|6. Carr NJ, McCarthy WF, Sobin LH. Epithelial non-carcinoid tumors and tumor-like lesions of the appendix. A clinicopathologic study of 184 patients with a multivariate analysis of prognostic factors. Cancer 1995;75:757-68. [DOI via Crossref] |
|7. Torlakovic E, Skovlund E, Snover DC, Torlakovic G, Nesland JM. Morphologic reappraisal of serrated colorectal polyps. Am J Surg Pathol 2003;27:65-81. [DOI via Crossref] [Pubmed] |
|8. Pai RK, Hartman DJ, Gonzalo DH, Lai KK, Downs-Kelly E, Goldblum JR, et al. Serrated lesions of the appendix frequently harbor KRAS mutations and not BRAF mutations indicating a distinctly different serrated neoplastic pathway in the appendix. Hum Pathol 2014;45:227-35. [DOI via Crossref] [Pubmed] |