eJManager
 
E-ISSN 2146-8362
 

Original Research Open Access


Effect of Semicarbazide on the Testis of Juvenile Male Albino Rat

Neveen M. El-Sherif, Abeer E. El-Mehi.

Cited by (1)

Abstract
Background: Semicarbazide (SEM) is an azodicarbonamide byproduct present in a glass jar packaged foods especially baby foods. A relatively high consumption of these products by infants can result in higher exposure compared with other consumers. Objectives: This study was performed to throw light on the effect of SEM on the testis of juvenile male albino rat.
Materials and Methods: This study was carried out on 20 juvenile male albino rats divided into the control group, and SEM treated group. Animals of the SEM treated group were administered 40 mg of SEM orally once daily for 30 days. At the end of the experiment, animals were weighed and then sacrificed. The parameters examined were gonadal index, epididymal spermatozoal examination, histological study, immunohistochemical staining for proliferating cell nuclear antigen (PCNA) in addition to ultrastructural study. Morphometric study and statistical analysis of the results were carried out.
Results: The gonadal index of SEM treated group showed a significant decrease compared with the control group. Loss of germ cells was confirmed by a significantly low sperm count. SEM induced variable degrees of tubular affection in the form of distorted seminiferous tubules, cellular disorganization, sloughing and cytoplasmic vacuolation. Acidophilic hyaline material, vacuolations, and congested blood vessels were present in most of the interstitial spaces. Immunohistochemically, SEM treatment induced a marked reduction in the number of PCNA immunoreactive cells. An ultrastructural alteration of spermatogenic cells and wide separation in between germ cells were observed.
Conclusions: These results suggest that growing animals are more susceptible to gonadal toxicity of SEM. It is better to avoid food products sold in glass jars, especially during the juvenile period.

Key words: Juvenile rat, semicarbazide, testis


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Export to
Export to
Related Records
 Articles by Neveen M. El-Sherif
Articles by Abeer E. El-Mehi
on Google
on Google Scholar
Article Statistics
 Viewed: 1373
Downloaded: 407
Cited: 1

REFERENCES
1. de la Calle MB, Anklam E. Semicarbazide: Occurrence in food products and state-of-the-art in analytical methods used for its determination. Anal Bioanal Chem 2005;382:968-77. [DOI via Crossref]    [Pubmed]   
2. Abramsson-Zetterberg L, Svensson K. Semicarbazide is not genotoxic in the flow cytometry-based micronucleus assay in vivo. Toxicol Lett 2005;155:211-7. [DOI via Crossref]    [Pubmed]   
3. Nestmann ER, Lynch BS, Musa Veloso K, Goodfellow GH, Cheng E, Haighton LA, et al. Safety assessment and risk-benefit analysis of the se of azodicarbonamide in baby food jar closure technology: Putting trace levels of semicarbazide exposure into perspective review. Food Addit Contam 2005;22:875-91. [DOI via Crossref]    [Pubmed]   
4. Saari L, Peltonen K. Novel source of semicarbazide: Levels of semicarbazide in cooked crayfish samples determined by LC/MS/ MS. Food Addit Contam 2004;21:825-32. [DOI via Crossref]    [Pubmed]   
5. Stadler RH, Mottier P, Guy P, Gremaud E, Varga N, Lalljie S, et al. Semicarbazide is a minor thermal decomposition product of azodicarbonamide used in the gaskets of certain food jars. Analyst 2004;129:276-81. [DOI via Crossref]    [Pubmed]   
6. Maranghi F, Tassinari R, Lagatta V, Moracci G, Macrì C, Eusepi A, et al. Effects of the food contaminant semicarbazide following oral administration in juvenile Sprague-Dawley rats. Food Chem Toxicol 2009;47:472-9. [DOI via Crossref]    [Pubmed]   
7. Takahashi M, Yoshida M, Inoue K, Morikawa T, Nishikawa A. A ninetyday toxicity study of semicarbazide hydrochloride in Wistar Hannover GALAS rats. Food Chem Toxicol 2009;47:2490-8. [DOI via Crossref]    [Pubmed]   
8. Mercier N, El Hadri K, Osborne-Pellegrin M, Nehme J, Perret C, Labat C, et al. Modifications of arterial phenotype in response to amine oxidase inhibition by semicarbazide. Hypertension 2007;50:234-41. [DOI via Crossref]    [Pubmed]   
9. Gong B, Trent MB, Srivastava D, Boor PJ. Chemical-induced, nonlethal, developmental model of dissecting aortic aneurysm. Birth Defects Res A Clin Mol Teratol 2006;76:29-38. [DOI via Crossref]    [Pubmed]   
10. Carreau S, Bourguiba S, Lambard S, Galeraud-Denis I, Genissel C, Levallet J. Reproductive system: Aromatase and estrogens. Mol Cell Endocrinol 2002;193:137-43. [DOI via Crossref]   
11. Yano CL, Dolder H. Rat testicular structure and ultrastructure after paracetamol treatment. Contraception 2002;66:463-7. [DOI via Crossref]   
12. Xue LY, Zhang XH, Xing LX, Li J, Wang GX. Serum hormone and cellular proliferation changes of testis in rats with experimental orchitis induced by lipopolysaccharide. J Reprod Contracept 2007;18:181-6. [DOI via Crossref]   
13. Tousson E, El-Moghazy M, Massoud A, Akel A. Histopathological and immunohistochemical changes in the testes of rabbits after injection with the growth promoter boldenone. Reprod Sci 2012;19:253-9. [DOI via Crossref]    [Pubmed]   
14. França LR, Suescun MO, Miranda JR, Giovambattista A, Perello M, Spinedi E, et al. Testis structure and function in a nongenetic hyperadipose rat model at prepubertal and adult ages. Endocrinology 2006;147:1556-63. [DOI via Crossref]    [Pubmed]   
15. Blazak WF, Treinen KA, Juniewicz PE. Application of testicular sperm head counts in the assessment of male reproductive toxicity. In: Chapin RE, Heindel JJ, editors. Methods in Toxicology. Part A, Male Reproductive Toxicology. Vol.3. San Diego: Academic Press Inc.; 1993.
16. Tardif S, Laforest JP, Cormier N, Bailey JL. The importance of porcine sperm parameters on fertility in vivo. Theriogenology 1999;52:447-59. [DOI via Crossref]   
17. Shivji KK, Kenny MK, Wood RD. Proliferating cell nuclear antigen is required for DNA excision repair. Cell 1992;69:367-74. [DOI via Crossref]   
18. Glauert AM, Lewis PR. Biological specimen preparation for transmission electron microscopy. 1st ed. London: Portland Press; 1998.
19. Cooper KM, Kennedy DG. Stability studies of the metabolites of nitrofuran antibiotics during storage and cooking. Food Addit Contam 2007;24:935-42. [DOI via Crossref]    [Pubmed]   
20. Ramos A, Pereira A, Cabrita AS, Capela e Silva F. Effects of the food contaminant semicarbazide on testicular morphology of juvenile wistar rats. Arq Bras Med Vet Zootec 2012;64:781-5. [DOI via Crossref]   
21. Sun JG, Jurisicova A, Casper RF. Detection of deoxyribonucleic acid fragmentation in human sperm: Correlation with fertilization in vitro. Biol Reprod 1997;56:602-7. [DOI via Crossref]    [Pubmed]   
22. Malekinejad H, Mirzakhani N, Razi M, Cheraghi H, Alizadeh A, Dardmeh F. Protective effects of melatonin and Glycyrrhiza glabra extract on ochratoxin A – induced damages on testes in mature rats. Hum Exp Toxicol 2011;30:110-23. [DOI via Crossref]    [Pubmed]   
23. Hayes T, Haston K, Tsui M, Hoang A, Haeffele C, Vonk A. Atrazineinduced hermaphroditism at 0.1 ppb in American leopard frogs (Rana pipiens): Laboratory and field evidence. Environ Health Perspect 2003;111:568-75. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
24. Dehkhargani SF, Shahrooz1 R, Malekinejad H. Atrazine in sub-acute exposure results in sperm DNA disintegrity and nuclear immaturity in rats. Vet Res Forum 2012;3:19-26.
25. Aitken RJ, Ryan AL, Baker MA, McLaughlin EA. Redox activity associated with the maturation and capacitation of mammalian spermatozoa. Free Radic Biol Med 2004;36:994-1010. [DOI via Crossref]    [Pubmed]   
26. Mathur PP, Saradha B, Vaithinathan S. Impact of environmental toxicants on testicular function. Immunol Endocr Metab Agents 2008;8:79-90. [DOI via Crossref]   
27. Kondo T, Shono T, Suita S. Age-specific effect of phthalate ester on testicular development in rats. J Pediatr Surg 2006;41:1290-3. [DOI via Crossref]    [Pubmed]   
28. Hirakawa K, Midorikawa K, Oikawa S, Kawanishi S. Carcinogenic semicarbazide induces sequence-specific DNA damage through the generation of reactive oxygen species and the derived organic radicals. Mutat Res 2003;536:91-101. [DOI via Crossref]   
29. Agarwal A, Gupta S, Sikka S. The role of free radicals and antioxidants in reproduction. Curr Opin Obstet Gynecol 2006;18:325-32. [DOI via Crossref]    [Pubmed]   
30. Fujii J, Iuchi Y, Matsuki S, Ishii T. Cooperative function of antioxidant and redox systems against oxidative stress in male reproductive tissues. Asian J Androl 2003;5:231-42.
31. Tripathi R, Mishra DP, Shaha C. Male germ cell development: Turning on the apoptotic pathways. J Reprod Immunol 2009;83:31-5. [DOI via Crossref]    [Pubmed]   
32. Lagos-Cabré R, Moreno RD. Contribution of environmental pollutants to male infertily: A working model of germ cell apoptosis induced by plasticizers. Biol Res 2012;45:5-14. [DOI via Crossref]    [Pubmed]   
33. Yamasaki H, Sandrof MA, Boekelheide K. Suppression of radiationinduced testicular germ cell apoptosis by 2,5-hexanedione pretreatment. I. Histopathological analysis reveals stage dependence of attenuated apoptosis. Toxicol Sci 2010;117:449-56. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
34. Creasy DM. Pathogenesis of male reproductive toxicity. Toxicol Pathol 2001;29:64-76. [DOI via Crossref]    [Pubmed]   
35. Rashed RM, Mohamed IK, EL-Alfy SH. Effects of two different doses of melatonin on the spermatogenic cells of rat testes: A light and electron microscopic study. Egypt J Histol 2010;33:819-35.
36. Moffit JS, Bryant BH, Hall SJ, Boekelheide K. Dose-dependent effects of sertoli cell toxicants 2,5-hexanedione, carbendazim, and mono-(2- ethylhexyl) phthalate in adult rat testis. Toxicol Pathol 2007;35:719-27. [DOI via Crossref]    [Pubmed]   
37. Manivannan B, Mittal R, Goyal S, Ansari AS, Lohiya NK. Sperm characteristics and ultrastructure of testes of rats after long-term treatment with the methanol subfraction of Carica papaya seeds. Asian J Androl 2009;11:583-99. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
38. Shalaby NM, Afifi OK. Effect of experimentally induced ischemic reperfusion on the testis and the possible protective role of l-carnitine in the adult albino rat; histological, histochemical and immunohistochemical study. Egypt J Histol 2008;31:233-44.
39. Paniagua R, Nistal M, Sáez FJ, Fraile B. Ultrastructure of the aging human testis. J Electron Microsc Tech 1991;19:241-60. [DOI via Crossref]    [Pubmed]   
40. Salama N, Bergh A, Damber JE. The changes in testicular vascular permeability during progression of the experimental varicocele. Eur Urol 2003;43:84-91. [DOI via Crossref]   
41. de Rooij DG, Russell LD. All you wanted to know about spermatogonia but were afraid to ask. J Androl 2000;21:776-98.
42. Tousson E, Ali EM, Ibrahim W, Mansour MA. Proliferating cell nuclear antigen as a molecular biomarker for spermatogenesis in PTU-induced hypothyroidism of rats. Reprod Sci 2011;18:679-86. [DOI via Crossref]    [Pubmed]   
43. Koh PO, Kim MO. Ethanol exposure decreases cell proliferation and increases apoptosis in rat testes. J Vet Med Sci 2006;68:1013-7. [DOI via Crossref]   
44. Zeng L, Kong XT, Su JW, Xia TL, Na YQ, Guo YL. Evaluation of germcell kinetics in infertile patients with proliferating cell nuclear antigen proliferating index. Asian J Androl 2001;3:63-6.
45. Hoenicke K, Gatermann R, Hartig L, Mandix M, Otte S. Formation of semicarbazide (SEM) in food by hypochlorite treatment: Is SEM a specific marker for nitrofurazone abuse? Food Addit Contam 2004;21:526-37.
46. Sugandhy O, Pannerdoss S, Suryavathi V. Toxic influence of mercuric chloride on antioxidant system in the testis and epididymis of albino rats. The 10th International Conference on Mercury as a Global Pollutant Halifax 2011;29: 45-100.
47. Tramer F, Rocco F, Micali F, Sandri G, Panfili E. Antioxidant systems in rat epididymal spermatozoa. Biol Reprod 1998;59:753-8. [DOI via Crossref]    [Pubmed]   
48. Baker LA, Turner TT. Leydig cell function after experimental testicular torsion despite loss of spermatogenesis. J Androl 1995;16:12-7.
49. Salman AB, Mutlu S, Iskit AB, Guc MO, Mutlu M, Tanyel FC. Hemodynamic monitoring of the contralateral testis during unilateral testicular torsion describes the mechanism of damage. Eur Urol 1998;33:576-80. [DOI via Crossref]    [Pubmed]   
50. Davidoff MS, Middendorff R, Müller D, Holstein AF. The neuroendocrine Leydig cells and their stem cell progenitors, the pericytes. Adv Anat Embryol Cell Biol 2009;205:1-107. [DOI via Crossref]    [Pubmed]   

This Article Cited By the following articles

Effect of aflatoxin B1 on the seminiferous tubules and the possible protective role of curcumin in adult albino rats (Light and electron microscopic study)
The Egyptian Journal of Histology 2015; 38(3): 614.

1
 

How to Cite this Article
Pubmed Style

El-Sherif NM, El-Mehi AE. Effect of Semicarbazide on the Testis of Juvenile Male Albino Rat. J Interdiscipl Histopathol. 2015; 3(1): 9-18. doi:10.5455/jihp.20150117112544


Web Style

El-Sherif NM, El-Mehi AE. Effect of Semicarbazide on the Testis of Juvenile Male Albino Rat. http://www.ejmjih.com/?mno=175314 [Access: February 23, 2018]. doi:10.5455/jihp.20150117112544


AMA (American Medical Association) Style

El-Sherif NM, El-Mehi AE. Effect of Semicarbazide on the Testis of Juvenile Male Albino Rat. J Interdiscipl Histopathol. 2015; 3(1): 9-18. doi:10.5455/jihp.20150117112544



Vancouver/ICMJE Style

El-Sherif NM, El-Mehi AE. Effect of Semicarbazide on the Testis of Juvenile Male Albino Rat. J Interdiscipl Histopathol. (2015), [cited February 23, 2018]; 3(1): 9-18. doi:10.5455/jihp.20150117112544



Harvard Style

El-Sherif, N. M. & El-Mehi, A. E. (2015) Effect of Semicarbazide on the Testis of Juvenile Male Albino Rat. J Interdiscipl Histopathol, 3 (1), 9-18. doi:10.5455/jihp.20150117112544



Turabian Style

El-Sherif, Neveen M., and Abeer E. El-Mehi. 2015. Effect of Semicarbazide on the Testis of Juvenile Male Albino Rat. Journal of Interdisciplinary Histopathology, 3 (1), 9-18. doi:10.5455/jihp.20150117112544



Chicago Style

El-Sherif, Neveen M., and Abeer E. El-Mehi. "Effect of Semicarbazide on the Testis of Juvenile Male Albino Rat." Journal of Interdisciplinary Histopathology 3 (2015), 9-18. doi:10.5455/jihp.20150117112544



MLA (The Modern Language Association) Style

El-Sherif, Neveen M., and Abeer E. El-Mehi. "Effect of Semicarbazide on the Testis of Juvenile Male Albino Rat." Journal of Interdisciplinary Histopathology 3.1 (2015), 9-18. Print. doi:10.5455/jihp.20150117112544



APA (American Psychological Association) Style

El-Sherif, N. M. & El-Mehi, A. E. (2015) Effect of Semicarbazide on the Testis of Juvenile Male Albino Rat. Journal of Interdisciplinary Histopathology, 3 (1), 9-18. doi:10.5455/jihp.20150117112544





Most Viewed Articles
  • Prevalence of Anemia and Associated Risk Factors among Pregnant Women Attending Antenatal Care in Azezo Health Center Gondar Town, Northwest Ethiopia
    Meseret Alem, Bamlaku Enawgaw, Aschalew Gelaw, Tigist Kenaw, Mohamed Seid , Yadesa Olkeba
    J Interdiscipl Histopathol. 2013; 1(3): 137-144
    » Abstract & References » doi: 10.5455/jihp.20130122042052

  • Cytomorphometric Analysis of Oral Premalignant and Malignant Lesions Using Feulgen Stain and Exfoliative Brush Cytology.
    Priya Shirish Joshi, Manasi Sandipak Kaijkar
    J Interdiscipl Histopathol. 2013; 1(4): 204-211
    » Abstract & References » doi: 10.5455/jihp.20130214064844

  • The Role of CD10 Immunohistochemistry in the Grading of Phyllodes Tumour of The Breast
    Huzlinda Hussin,Jayalakshmi Pailoor, Peh Suat Cheng
    J Interdiscipl Histopathol. 2013; 1(4): 195-203
    » Abstract & References » doi: 10.5455/jihp.20130307011432

  • Differences in the Angiogenesis of Benign and Malignant Surface Epithelial Ovarian Tumors Demonstrated by Microvessel Density and Immunohistochemistry
    Shelly Sehgal, Prashant Goyal, Reena Agarwal, Sompal Singh, Awanindra Kumar, Ruchika Gupta, Vinita Kumar, Dipti Agrawal
    J Interdiscipl Histopathol. 2013; 1(3): 145-152
    » Abstract & References » doi: 10.5455/jihp.20130204114930

  • Retroperitoneal Non-functioning Paraganglioma: A Case Report
    Faten Limaiem, Saadia Bouraoui, Sirine Bouslama, Sana Ben Slama, Ahlem Lahmar, Sabeh Mzabi-Regaya
    J Interdiscipl Histopathol. 2013; 1(3): 168-171
    » Abstract & References » doi: 10.5455/jihp.20130115114630

  • Nonspecific Cecal Ulcer: An Obsolete Jargon
    Duvuru Ram, Vilvapathy Senguttuvan Karthikeyan, Sarath Chandra Sistla
    J Interdiscipl Histopathol. 2013; 1(2): 85-88
    » Abstract & References » doi: 10.5455/jihp.20121228043742

  • P53 Immunohistochemical Staining Patterns in Benign, Premalignant and Malignant Lesions of the Oral Cavity: A Study of 68 Cases
    Pankaj Baweja, Vidya Monappa, Geetha Krishnanand
    J Interdiscipl Histopathol. 2013; 1(3): 113-120
    » Abstract & References » doi: 10.5455/jihp.20130121120725

  • Histopathology as diagnostic tool for Ascosphaera apis infection in apparently healthy honey bees (Apis mellifera ligustica)
    Paola Maiolino, Francesca Carella, Giovanna De Leva, Laura Rinaldi, Giuseppe Cringoli, Manuela Martano
    J Interdiscipl Histopathol. 2013; 1(3): 160-162
    » Abstract & References » doi: 10.5455/jihp.20130128010436

  • Double-Hit Lymphoma Presenting as Primary Renal Lymphoma: A Case Report
    Vikas Mehta, Chad Ellimottil, Jodi Speiser, Milind Velankar, Guliz A Barkan
    J Interdiscipl Histopathol. 2013; 1(2): 93-97
    » Abstract & References » doi: 10.5455/jihp.20130121075815

  • Lateral Periodontal Cyst: A Report of Two Cases with Varying Clinico-Radiological Features
    Preethi Balan, Subhas G Babu, Shishir Shetty, Deepa Dsouza
    J Interdiscipl Histopathol. 2012; 1(1): 41-44
    » Abstract & References » doi: 10.5455/jihp.20120808010902

  • Most Downloaded
  • Prevalence of Anemia and Associated Risk Factors among Pregnant Women Attending Antenatal Care in Azezo Health Center Gondar Town, Northwest Ethiopia
    Meseret Alem, Bamlaku Enawgaw, Aschalew Gelaw, Tigist Kenaw, Mohamed Seid , Yadesa Olkeba
    J Interdiscipl Histopathol. 2013; 1(3): 137-144
    » Abstract & References » doi: 10.5455/jihp.20130122042052

  • Cytomorphometric Analysis of Oral Premalignant and Malignant Lesions Using Feulgen Stain and Exfoliative Brush Cytology.
    Priya Shirish Joshi, Manasi Sandipak Kaijkar
    J Interdiscipl Histopathol. 2013; 1(4): 204-211
    » Abstract & References » doi: 10.5455/jihp.20130214064844

  • P53 Immunohistochemical Staining Patterns in Benign, Premalignant and Malignant Lesions of the Oral Cavity: A Study of 68 Cases
    Pankaj Baweja, Vidya Monappa, Geetha Krishnanand
    J Interdiscipl Histopathol. 2013; 1(3): 113-120
    » Abstract & References » doi: 10.5455/jihp.20130121120725

  • Small Cell Lung Carcinoma: Better Than Its Reputation? A Population Based Study
    Hans Rostad, Erik Heyerdahl Strom, Helge Scott, Maria Ramnefjell, Kjell Kjellevold
    J Interdiscipl Histopathol. 2012; 1(1): 1-4
    » Abstract & References » doi: 10.5455/jihp.20120703032839

  • Histopathology of the Liver Following Administration of Artesunate in Adult Wistar Rats
    Felix Monday Onyije, Josiah S Hart
    J Interdiscipl Histopathol. 2012; 1(1): 26-29
    » Abstract & References » doi: 10.5455/jihp.20120606081137

  • Lateral Periodontal Cyst: A Report of Two Cases with Varying Clinico-Radiological Features
    Preethi Balan, Subhas G Babu, Shishir Shetty, Deepa Dsouza
    J Interdiscipl Histopathol. 2012; 1(1): 41-44
    » Abstract & References » doi: 10.5455/jihp.20120808010902

  • Stented Vessels: A Challenge for Histological Preparation and Microscopy
    Andrea Nolte, Theresa Braun, Sven Zur Oven Krockhaus, Adelheid Munz, Ulrich Vogel, Christian Schlensak, Hans Wendel, Tobias Walker
    J Interdiscipl Histopathol. 2013; 1(3): 104-112
    » Abstract & References » doi: 10.5455/jihp.20130306112937

  • Role of HPV Vaccine in the Prevention of Cervical Cancer
    Saleh JA, Yusuph H, Zailani ZB
    J Interdiscipl Histopathol. 2013; 1(4): 212-216
    » Abstract & References » doi: 10.5455/jihp.20130119122700

  • The Role of CD10 Immunohistochemistry in the Grading of Phyllodes Tumour of The Breast
    Huzlinda Hussin,Jayalakshmi Pailoor, Peh Suat Cheng
    J Interdiscipl Histopathol. 2013; 1(4): 195-203
    » Abstract & References » doi: 10.5455/jihp.20130307011432

  • Histopathological Effects of Varied Fluoride Concentration on Cerebrum in Albino Rats
    Sajad Hamid, Zaffar Kawoosa, Shahnawaz Hamid, M.A. Mir, Athar Hafiz, Irfan Jan, Fayiza Yaqoob
    J Interdiscipl Histopathol. 2012; 1(1): 30-34
    » Abstract & References » doi: 10.5455/jihp.20121105123701

  • Most Cited Articles
  • Prevalence of Anemia and Associated Risk Factors among Pregnant Women Attending Antenatal Care in Azezo Health Center Gondar Town, Northwest Ethiopia
    Meseret Alem, Bamlaku Enawgaw, Aschalew Gelaw, Tigist Kenaw, Mohamed Seid , Yadesa Olkeba
    J Interdiscipl Histopathol. 2013; 1(3): 137-144
    » Abstract & References » doi: 10.5455/jihp.20130122042052
    Cited : 17 times [Click to see citing articles]

  • Renal Biopsy for Research: An Overview of Russian Experience
    Sergei V. Jargin
    J Interdiscipl Histopathol. 2014; 2(2): 88-95
    » Abstract & References » doi: 10.5455/jihp.20140312020838
    Cited : 4 times [Click to see citing articles]

  • The Senescence Process of Internal Thoracic Artery
    Antonio Manenti, Luca Roncati, Giuseppe Barbolini, Francesco Rivasi
    J Interdiscipl Histopathol. 2013; 1(2): 58-61
    » Abstract & References » doi: 10.5455/jihp.20121211115233
    Cited : 3 times [Click to see citing articles]

  • Primary Biliary Cirrhosis Overlapping with Autoimmune Hepatitis in an HIV-Infected Patient on Antiretroviral Therapy
    Margaret Rae Caplan, Apurva Trivedi, Mary McLaughlin, Annick Hebou, David Kleiner, Theo Heller, Caryn Morse
    J Interdiscipl Histopathol. 2013; 1(5): 270-273
    » Abstract & References » doi: 10.5455/jihp.20130624104921
    Cited : 3 times [Click to see citing articles]

  • Evaluation of Amelotin Expression in Benign Odontogenic Tumors
    Daiana Paula Stolf, Tae-Young Lee, Grace Bradley, Bernhard Ganss
    J Interdiscipl Histopathol. 2013; 1(5): 236-245
    » Abstract & References » doi: 10.5455/jihp.20130506045106
    Cited : 2 times [Click to see citing articles]

  • Diffuse Cutaneous Leishmaniasis in an HIV Sero-Positive Patient - A Diagnostic Dilemma
    Kumar U Mahesh, Balasaheb Ramling Yelikar, Ratnakar Madhav Rao Potekar, Palin Aparna, Murthy Keshav
    J Interdiscipl Histopathol. 2012; 1(1): 45-47
    » Abstract & References » doi: 10.5455/jihp.20121109060828
    Cited : 2 times [Click to see citing articles]

  • Small Cell Lung Carcinoma: Better Than Its Reputation? A Population Based Study
    Hans Rostad, Erik Heyerdahl Strom, Helge Scott, Maria Ramnefjell, Kjell Kjellevold
    J Interdiscipl Histopathol. 2012; 1(1): 1-4
    » Abstract & References » doi: 10.5455/jihp.20120703032839
    Cited : 2 times [Click to see citing articles]

  • Association of Claudin-1 with E-Cadherin/Catenin Complex, Microvessel Density (MVD)-Related Markers, and Clinicopathological Features in Colorectal Carcinoma
    Urania Skoufi, Dimitrios L Arvanitis, Litsa Lampri, Elli Ioachim, Jim Koutsogiannis, Christina Skoufi, Dimitris Tsironis and Antigony Mitselou
    J Interdiscipl Histopathol. 2014; 2(3): 135-144
    » Abstract & References » doi: 10.5455/jihp.20140429121735
    Cited : 2 times [Click to see citing articles]

  • Cadmium-Induced Testicular Toxicity, Oxidative Stress and Histopathology in Wistar Rats: Sustained Effects of Polyphenol-Rich Extract of Vernonia Amygdalina (Del.) Leaf
    Christian Eseigbe Imafidon, Olatoye Taiwo Risikat, Bamidele Funminiyi Samuel, Ojo Opeyemi Esther, Ademoye Kehinde Aderonke
    J Interdiscipl Histopathol. 2016; 4(3): 54-62
    » Abstract & References » doi: 10.5455/jihp.20160618041629
    Cited : 2 times [Click to see citing articles]

  • Histopathological Effects of Varied Fluoride Concentration on Cerebrum in Albino Rats
    Sajad Hamid, Zaffar Kawoosa, Shahnawaz Hamid, M.A. Mir, Athar Hafiz, Irfan Jan, Fayiza Yaqoob
    J Interdiscipl Histopathol. 2012; 1(1): 30-34
    » Abstract & References » doi: 10.5455/jihp.20121105123701
    Cited : 2 times [Click to see citing articles]