E-ISSN 2146-8362
 

Original Research 


Histopathology of the Liver Following Administration of Artesunate in Adult Wistar Rats

Felix Monday Onyije, Josiah S Hart.

Abstract
Summary
In must of the developing countries especially in Africa antimalaria drugs are taken regularly either to treat or prevent malaria. The rats were randomly divided into 3 groups of 5 each and tested as follows: - Group O- control (water), Group A – 2mg/kg and Group B - 6mg/kg. The animals were sacrificed after the 7th day. There was no mortality caused by the drug but dizziness in the animals. In the group administered with 2mg/kg of oral artesunate where was no form of distortion in the tissue architecture of the liver, but in the group administered with 6mg/kg of artesunate, artesunate caused sinusoidal congestion, infiltration of inflammatory cells and there was loss of tissue architecture. Drugs are produce to combat illnesses but may turn out be harmful when administered wrongly. In must of the developing countries especially in Africa antimalaria drugs are taken regularly either to treat or prevent malaria. They are taken such that one could even imaging if it is a food supplement.

Key words: Histopathology, Drug Abuse, Hepatocyte, Inflammatory cells, Malaria.


 
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How to Cite this Article
Pubmed Style

Onyije FM, Hart JS. Histopathology of the Liver Following Administration of Artesunate in Adult Wistar Rats. J Interdiscip Histopathol. 2012; 1(1): 26-29. doi:10.5455/jihp.20120606081137


Web Style

Onyije FM, Hart JS. Histopathology of the Liver Following Administration of Artesunate in Adult Wistar Rats. http://www.ejmjih.com/?mno=17279 [Access: July 17, 2018]. doi:10.5455/jihp.20120606081137


AMA (American Medical Association) Style

Onyije FM, Hart JS. Histopathology of the Liver Following Administration of Artesunate in Adult Wistar Rats. J Interdiscip Histopathol. 2012; 1(1): 26-29. doi:10.5455/jihp.20120606081137



Vancouver/ICMJE Style

Onyije FM, Hart JS. Histopathology of the Liver Following Administration of Artesunate in Adult Wistar Rats. J Interdiscip Histopathol. (2012), [cited July 17, 2018]; 1(1): 26-29. doi:10.5455/jihp.20120606081137



Harvard Style

Onyije, F. M. & Hart, J. S. (2012) Histopathology of the Liver Following Administration of Artesunate in Adult Wistar Rats. J Interdiscip Histopathol, 1 (1), 26-29. doi:10.5455/jihp.20120606081137



Turabian Style

Onyije, Felix Monday, and Josiah S Hart. 2012. Histopathology of the Liver Following Administration of Artesunate in Adult Wistar Rats. Journal of Interdisciplinary Histopathology, 1 (1), 26-29. doi:10.5455/jihp.20120606081137



Chicago Style

Onyije, Felix Monday, and Josiah S Hart. "Histopathology of the Liver Following Administration of Artesunate in Adult Wistar Rats." Journal of Interdisciplinary Histopathology 1 (2012), 26-29. doi:10.5455/jihp.20120606081137



MLA (The Modern Language Association) Style

Onyije, Felix Monday, and Josiah S Hart. "Histopathology of the Liver Following Administration of Artesunate in Adult Wistar Rats." Journal of Interdisciplinary Histopathology 1.1 (2012), 26-29. Print. doi:10.5455/jihp.20120606081137



APA (American Psychological Association) Style

Onyije, F. M. & Hart, J. S. (2012) Histopathology of the Liver Following Administration of Artesunate in Adult Wistar Rats. Journal of Interdisciplinary Histopathology, 1 (1), 26-29. doi:10.5455/jihp.20120606081137





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