E-ISSN 2146-8362
 

Review Article 


Arterial and Arteriolar Lesions in Renal Allografts: A Differential Diagnostic Approach

Anjali A Satoskar, Sergey V Brodsky, Gyongyi M Nadasdy, Tibor Nadasdy.

Abstract
Renal allograft pathology is quite a complex issue and has been addressed in many monographs and book chapters. Renal allografts can fail secondary to rejection, but recurrent renal diseases and de novo diseases affecting the allograft may also contribute to the demise of the transplanted kidney. As a pathologist, one needs to examine the four compartments of the kidney (glomeruli, tubules, interstitium, and vasculature) separately and integrate the histology with the clinical presentation. Although glomerular and tubulointerstitial changes can be quite relevant in terms of renal allograft outcome and prognosis, correct evaluation of arterial/arteriolar changes in a renal allograft is crucial in making the appropriate diagnosis and the arterial/arteriolar changes may provide relevant prognostic information.
The pathologist should very carefully study and describe the vascular changes in a renal allograft and correlate them with clinical findings. If arteries are not present, or if only a single or two small terminal interlobular arteries are seen, the biopsy report should indicate this and draw attention to possible sampling errors and to limited informative value of the specimen.
In this review, we will try to provide a short review on vascular changes in renal allografts with a differential diagnostic approach.

Key words: Vascular changes; allograft; kidney; transplantation; histopathology


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Export to
Export to
Related Records
 Articles by Anjali A Satoskar
Articles by Sergey V Brodsky
Articles by Gyongyi M Nadasdy
Articles by Tibor Nadasdy
on Google
on Google Scholar
Article Statistics
 Viewed: 1488
Downloaded: 484
Cited: 0

REFERENCES
1. Racusen LC, Solez K, Colvin RB, Bonsib SM, Castro MC, Cavallo T, Croker BP, Demetris AJ, Drachenberg CB, Fogo AB, Furness P, Gaber LW, Gibson IW, Glotz D, Goldberg JC, Grande J, Halloran PF, Hansen HE, Hartley B, Hayry PJ, Hill CM, Hoffman EO, Hunsicker LG, Lindblad AS, Yamaguchi Y. The Banff 97 working classification of renal allograft pathology. Kidney International 1999;55(2):713-723. [DOI via Crossref]    [Pubmed]   
2. Nickeleit V, Vamvakas EC, Pascual M, Poletti BJ, Colvin RB. The prognostic significance of specific arterial lesions in acute renal allograft rejection. Journal of the American Society of Nephrology 1998;9(7):1301-1308. [Pubmed]   
3. Haas M, Kraus ES, Samaniego-Picota M, Racusen LC, Ni W, Eustace JA. Acute renal allograft rejection with intimal arteritis: histologic predictors of response to therapy and graft survival. Kidney International 2002;61(4):1516-1526. [DOI via Crossref]    [Pubmed]   
4. Shimizu T, Ishida H, Shirakawa H, Omoto K, Tsunoyama K, Tokumoto T, Tanabe K. Clinicopathological analysis of acute vascular rejection cases after renal transplantation. Clinical Transplantation 2010;24 Suppl 22:22-26. [DOI via Crossref]    [Pubmed]   
5. Shimizu T, Tanabe T, Omoto K, Ishida H, Tanabe K. Clinicopathologic analysis of acute vascular rejection cases after renal transplantation. Transplantation Proceedings 2012;44(1):230-5. [DOI via Crossref]    [Pubmed]   
6. Nadasdy T, Satoskar A, Nadasdy G. Pathology of Renal Transplantation. In: Zhou XJ LZ, Nadasdy T, et al., editor. Silva's Diagnostic Renal Pathology. New York: Cambridge University Press; 2009. p. 522-567.
7. Laszik ZG, Silva FG. Thrombotic Microangiopathies. In: Jennette JC, Olson JL, Schwartz MM, Silva FG (Eds). Heptinstall's Pathology of the Kidney. 7th Edition ed. Philadelphia, PA: Lippincott, Williams, & Wilkins; In Press.
8. Barbour T, Johnson S, Cohney S, Hughes P. Thrombotic microangiopathy and associated renal disorders. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2012;27(7):2673-2685. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
9. Noris M, Remuzzi G. Atypical hemolytic-uremic syndrome. The New England Journal of Medicine 2009;361(17):1676-1687. [DOI via Crossref]    [Pubmed]   
10. Besbas N, Karpman D, Landau D, Loirat C, Proesmans W, Remuzzi G, Rizzoni G, Taylor CM, Van de Kar N, Zimmerhackl LB; European Paediatric Research Group for HUS. A classification of hemolytic uremic syndrome and thrombotic thrombocytopenic purpura and related disorders. Kidney International 2006;70(3):423-431. [Pubmed]   
11. Kavanagh D, Goodship TH, Richards A. Atypical hemolytic uremic syndrome. Seminars in Nephrology 2013;33(6):508-530. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
12. Noris M, Remuzzi G. Genetics and genetic testing in hemolytic uremic syndrome/thrombotic thrombocytopenic purpura. Seminars in Nephrology 2010;30(4):395-408. [DOI via Crossref]    [Pubmed]   
13. Bu F, Maga T, Meyer NC, Wang K, Thomas CP, Nester CM, Simith RJ. Comprehensive genetic analysis of complement and coagulation genes in atypical hemolytic uremic syndrome. Journal of the American Society of Nephrology 2014;25(1):55-64. [DOI via Crossref]    [Pubmed]   
14. Noris M, Remuzzi G. Thrombotic microangiopathy after kidney transplantation. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2010;10(7):1517-1523. [DOI via Crossref]    [Pubmed]   
15. Bresin E, Daina E, Noris M, Castelletti F, Stefanov R, Hill P, Goodship TH, Remuzzi G; International Registry of Recurrent and Familial HUS/TTP. Outcome of renal transplantation in patients with non-Shiga toxin-associated hemolytic uremic syndrome: prognostic significance of genetic background. Clinical journal of the American Society of Nephrology 2006;1(1):88-99. [DOI via Crossref]    [Pubmed]   
16. Kavanagh D, Richards A, Goodship T, Jalanko H. Transplantation in atypical hemolytic uremic syndrome. Seminars in thrombosis and hemostasis. 2010;36(6):653-659. [DOI via Crossref]    [Pubmed]   
17. Tang W, Mohandas J, McDonald SP, Hawley CM, Badve SV, Boudville N, Brown FG, Clayton PA, Wiggins KJ, Bannister KM, Campbell SB, Johnson DW. End-stage kidney disease due to haemolytic uraemic syndrome--outcomes in 241 consecutive ANZDATA registry cases. BMC Nephrology 2012;13:164. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
18. Seitz B, Albano L, Vocila F, Mzoughi S, Aoudia R, Guitard J, Ribes D, Vachet-Copponat H, Mourad G, Bienaimé F, Dahan P, Frémeaux-Bacchi V, Cassuto E. Recurrence of hemolytic uremic syndrome after renal transplantation. Transplantation Proceedings 2007;39(8):2583-2585. [DOI via Crossref]    [Pubmed]   
19. Loirat C, Fremeaux-Bacchi V. Hemolytic uremic syndrome recurrence after renal transplantation. Pediatric Transplantation 2008;12(6):619-629. [DOI via Crossref]    [Pubmed]   
20. Cochat P, Fargue S, Mestrallet G, Jungraithmayr T, Koch-Nogueira P, Ranchin B, Zimmerhackl LB. Disease recurrence in paediatric renal transplantation. Pediatric Nephrology 2009;24(11):2097-2108. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
21. Chan MR, Thomas CP, Torrealba JR, Djamali A, Fernandez LA, Nishimura CJ, Smith RJ, Samaniego MD. Recurrent atypical hemolytic uremic syndrome associated with factor I mutation in a living related renal transplant recipient. American Journal of Kidney Diseases 2009;53(2):321-326. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
22. Le Quintrec M, Zuber J, Moulin B, Kamar N, Jablonski M, Lionet A, Chatelet V, Mousson C, Mourad G, Bridoux F, Cassuto E, Loirat C, Rondeau E, Delahousse M, Frémeaux-Bacchi V. Complement genes strongly predict recurrence and graft outcome in adult renal transplant recipients with atypical hemolytic and uremic syndrome. American Journal of Transplantation 2013;13(3):663-675. [DOI via Crossref]    [Pubmed]   
23. Reynolds JC, Agodoa LY, Yuan CM, Abbott KC. Thrombotic microangiopathy after renal transplantation in the United States. American Journal of Kidney Diseases 2003;42(5):1058-1068. [DOI via Crossref]    [Pubmed]   
24. Caires RA, Marques ID, Repizo LP, Sato VA, Carmo LP, Machado DJ, de Paula FJ, Nahas WC, David-Neto E. De novo thrombotic microangiopathy after kidney transplantation: clinical features, treatment, and long-term patient and graft survival. Transplantation Proceedings 2012;44(8):2388-2390. [DOI via Crossref]    [Pubmed]   
25. Satoskar AA, Pelletier R, Adams P, Nadasdy GM, Brodsky S, Pesavento T, Henry M, Nadasdy T. De novo thrombotic microangiopathy in renal allograft biopsies-role of antibody-mediated rejection. American Journal of Transplantation 2010;10(8):1804-1811. [DOI via Crossref]    [Pubmed]   
26. Schwimmer J, Nadasdy TA, Spitalnik PF, Kaplan KL, Zand MS. De novo thrombotic microangiopathy in renal transplant recipients: a comparison of hemolytic uremic syndrome with localized renal thrombotic microangiopathy. American Journal of Kidney Diseases 2003;41(2):471-479. [DOI via Crossref]    [Pubmed]   
27. Halloran PF, de Freitas DG, Einecke G, Famulski KS, Hidalgo LG, Mengel M, Reeve J, Sellares J, Sis B. The molecular phenotype of kidney transplants. American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2010;10(10):2215-2222. [DOI via Crossref]    [Pubmed]   
28. Mengel M, Campbell P, Gebel H, Randhawa P, Rodriguez ER, Colvin R, Conway J, Hachem R, Halloran PF, Keshavjee S, Nickerson P, Murphey C, O'Leary J, Reeve J, Tinckam K, Reed EF. Precision diagnostics in transplantation: from bench to bedside. American Journal of Transplantation 2013;13(3):562-568. [DOI via Crossref]    [Pubmed]   
29. Drachenberg CB, Papadimitriou JC. Endothelial injury in renal antibody-mediated allograft rejection: a schematic view based on pathogenesis. Transplantation 2013;95(9):1073-1083. [DOI via Crossref]    [Pubmed]   
30. Husain S, Sis B. Advances in the understanding of transplant glomerulopathy. American Journal of Kidney Diseases 2013;62(2):352-363. [DOI via Crossref]    [Pubmed]   
31. Baid-Agrawal S, Farris AB, 3rd, Pascual M, Mauiyyedi S, Farrell ML, Tolkoff-Rubin N, Collins AB, Frei U, Colvin RB. Overlapping pathways to transplant glomerulopathy: chronic humoral rejection, hepatitis C infection, and thrombotic microangiopathy. Kidney International 2011;80(8):879-885. [DOI via Crossref]    [Pubmed]   
32. Baid S, Pascual M, Williams WW, Jr., Tolkoff-Rubin N, Johnson SM, Collins B, Chung RT, Delmonico FL, Cosimi AB, Colvin RB. Renal thrombotic microangiopathy associated with anticardiolipin antibodies in hepatitis C-positive renal allograft recipients. Journal of the American Society of Nephrology 1999;10(1):146-153. [Pubmed]   
33. Agustian PA, Bockmeyer CL, Modde F, Wittig J, Heinemann FM, Brundiers S, Dämmrich ME, Schwarz A, Birschmann I, Suwelack B, Jindra PT, Ahlenstiel T, Wohlschläger J, Vester U, Ganzenmüller T, Zilian E, Feldkamp T, Spieker T, Immenschuh S, Kreipe HH, Bröcker V, Becker JU. Glomerular mRNA expression of prothrombotic and antithrombotic factors in renal transplants with thrombotic microangiopathy. Transplantation 2013;95(10):1242-1248. [DOI via Crossref]    [Pubmed]   
34. Randhawa PS, Tsamandas AC, Magnone M, Jordan M, Shapiro R, Starzl TE, Demetris AJ. Microvascular changes in renal allografts associated with FK506 (Tacrolimus) therapy. The American Journal of Surgical Pathology 1996;20(3):306-312. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
35. Young BA, Marsh CL, Alpers CE, Davis CL. Cyclosporine-associated thrombotic microangiopathy/hemolytic uremic syndrome following kidney and kidney-pancreas transplantation. American Journal of Kidney Diseases 1996;28(4):561-571. [DOI via Crossref]   
36. Zent R, Katz A, Quaggin S, Cattran D, Wade J, Cardella C, Zaltzman J, Fenton S, Cole E. Thrombotic microangiopathy in renal transplant recipients treated with cyclosporin A. Clinical Nephrology 1997;47(3):181-186. [Pubmed]   
37. Zarifian A, Meleg-Smith S, O'Donovan R, Tesi RJ, Batuman V. Cyclosporine-associated thrombotic microangiopathy in renal allografts. Kidney International 1999;55(6):2457-2466. [DOI via Crossref]    [Pubmed]   
38. Remuzzi G, Bertani T. Renal vascular and thrombotic effects of cyclosporine. American Journal of Kidney Diseases 1989;13(4):261-272. [DOI via Crossref]   
39. Tomasiak M, Rusak T, Gacko M, Stelmach H. Cyclosporine enhances platelet procoagulant activity. Nephrology, Dialysis, Transplantation 2007;22(6):1750-1756. [DOI via Crossref]    [Pubmed]   
40. Morozumi K, Takeda A, Uchida K, Mihatsch MJ. Cyclosporine nephrotoxicity: how does it affect renal allograft function and transplant morphology? Transplantation Proceedings 2004;36(2 Suppl):251S-256S. [DOI via Crossref]    [Pubmed]   
41. Yilmaz VT, Kocak H, Avci AB, Salim O, Ersoy FF, Suleymanlar G. Thrombotic thrombocytopenic purpura associated with everolimus use in a renal transplant patient. International Urology and Nephrology 2011;43(2):581-584. [DOI via Crossref]    [Pubmed]   
42. Carmona A, Diaz-Ricart M, Palomo M, Molina P, Pino M, Rovira M, Escolar G, Carreras E. Distinct deleterious effects of cyclosporine and tacrolimus and combined tacrolimus-sirolimus on endothelial cells: protective effect of defibrotide. Biology of Blood and Marrow Transplantation 2013;19(10):1439-1445. [DOI via Crossref]    [Pubmed]   
43. Habib A, Karmali V, Polavarapu R, Akahori H, Nakano M, Yazdani S, Otsuka F, Pachura K, Davis T, Narula J, Kolodgie FD, Virmani R, Finn AV. Metformin impairs vascular endothelial recovery after stent placement in the setting of locally eluted mammalian target of rapamycin inhibitors via S6 kinase-dependent inhibition of cell proliferation. Journal of the American College of Cardiology 2013;61(9):971-980. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
44. Dormond-Meuwly A, Roulin D, Dufour M, Benoit M, Demartines N, Dormond O. The inhibition of MAPK potentiates the anti-angiogenic efficacy of mTOR inhibitors. Biochemical and Biophysical Research Communications 2011;407(4):714-719. [DOI via Crossref]    [Pubmed]   
45. Meehan SM, Kremer J, Ali FN, Curley J, Marino S, Chang A, Kadambi PV. Thrombotic microangiopathy and peritubular capillary C4d expression in renal allograft biopsies. Clinical journal of the American Society of Nephrology 2011;6(2):395-403. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
46. Canaud G, Bienaime F, Noel LH, Royal V, Alyanakian MA, Dautzenberg MD, Rabant M, Posson J, Thervet E, Anglicheau D, Kreis H, Martinez F, Legendre C, Zuber J. Severe vascular lesions and poor functional outcome in kidney transplant recipients with lupus anticoagulant antibodies. American Journal of Transplantation 2010;10(9):2051-2060. [DOI via Crossref]    [Pubmed]   
47. Canaud G, Kamar N, Anglicheau D, Esposito L, Rabant M, Noel LH, Guilbeau-Frugier C, Sberro-Soussan R, Del Bello A, Martinez F, Zuber J, Rostaing L, Legendre C. Eculizumab improves posttransplant thrombotic microangiopathy due to antiphospholipid syndrome recurrence but fails to prevent chronic vascular changes. American Journal of Transplantation 2013;13(8):2179-2185. [DOI via Crossref]    [Pubmed]   
48. Iwami D, Harada H, Hotta K, Miura M, Seki T, Togashi M, Hirano T. A case of pregnancy-induced thrombotic thrombocytopenic purpura with a kidney allograft recipient. Clinical Transplantation 2010;24 Suppl 22:66-69. [DOI via Crossref]    [Pubmed]   
49. Ardalan MR, Shoja MM, Tubbs RS, Jayne D. Parvovirus B19 microepidemic in renal transplant recipients with thrombotic microangiopathy and allograft vasculitis. Experimental and Clinical Transplantation 2008;6(2):137-143. [Pubmed]   
50. Brodin-Sartorius A, Mekki Y, Bloquel B, Rabant M, Legendre C. [Parvovirus B19 infection after kidney transplantation]. Nephrologie and Therapeutique 2012;8(1):5-12. [DOI via Crossref]    [Pubmed]   
51. Murer L, Zacchello G, Bianchi D, Dall'Amico R, Montini G, Andreetta B, Perini M, Dossi EC, Zanon G, Zacchello F. Thrombotic microangiopathy associated with parvovirus B 19 infection after renal transplantation. Journal of the American Society of Nephrology 2000;11(6):1132-1137. [Pubmed]   
52. De Keyzer K, Van Laecke S, Peeters P, Vanholder R. De novo thrombotic microangiopathy induced by cytomegalovirus infection leading to renal allograft loss. American Journal of Nephrology 2010;32(5):491-496. [DOI via Crossref]    [Pubmed]   
53. Rane S, Nada R, Minz M, Sakhuja V, Joshi K. Spectrum of cytomegalovirus-induced renal pathology in renal allograft recipients. Transplantation Proceedings 2012;44(3):713-716. [DOI via Crossref]    [Pubmed]   
54. Le Quintrec M, Lionet A, Kamar N, Karras A, Barbier S, Buchler M, Fakhouri F, Provost F, Fridman WH, Thervet E, Legendre C, Zuber J, Frémeaux-Bacchi V. Complement mutation-associated de novo thrombotic microangiopathy following kidney transplantation. American journal of transplantation 2008;8(8):1694-1701. [DOI via Crossref]    [Pubmed]   
55. Zuber J, Le Quintrec M, Morris H, Fremeaux-Bacchi V, Loirat C, Legendre C. Targeted strategies in the prevention and management of atypical HUS recurrence after kidney transplantation. Transplantation Reviews 2013;27(4):117-125. [DOI via Crossref]    [Pubmed]   
56. Ripple MG, Charney D, Nadasdy T. Cholesterol embolization in renal allografts. Transplantation 2000;69(10):2221-2225. [DOI via Crossref]    [Pubmed]   
57. Lai CK, Randhawa PS. Cholesterol embolization in renal allografts: a clinicopathologic study of 12 cases. The American Journal of Surgical Pathology 2007;31(4):536-545. [DOI via Crossref]    [Pubmed]   
58. Mihatsch MJ, Thiel G, Basler V, Ryffel B, Landmann J, von Overbeck J, Zollinger HU. Morphological patterns in cyclosporine-treated renal transplant recipients. Transplantation Proceedings 1985;17(4 Suppl 1):101-116. [Pubmed]   
59. Sibley RK, Rynasiewicz J, Ferguson RM, Fryd D, Sutherland DE, Simmons RL, Najarian JS. Morphology of cyclosporine nephrotoxicity and acute rejection in patients immunosuppressed with cyclosporine and prednisone. Surgery 1983;94(2):225-234. [Pubmed]   

How to Cite this Article
Pubmed Style

Satoskar AA, Brodsky SV, Nadasdy GM, Nadasdy T. Arterial and Arteriolar Lesions in Renal Allografts: A Differential Diagnostic Approach. J Interdiscip Histopathol. 2014; 2(3): 121-134. doi:10.5455/jihp.20140708044111


Web Style

Satoskar AA, Brodsky SV, Nadasdy GM, Nadasdy T. Arterial and Arteriolar Lesions in Renal Allografts: A Differential Diagnostic Approach. http://www.ejmjih.com/?mno=163919 [Access: August 16, 2018]. doi:10.5455/jihp.20140708044111


AMA (American Medical Association) Style

Satoskar AA, Brodsky SV, Nadasdy GM, Nadasdy T. Arterial and Arteriolar Lesions in Renal Allografts: A Differential Diagnostic Approach. J Interdiscip Histopathol. 2014; 2(3): 121-134. doi:10.5455/jihp.20140708044111



Vancouver/ICMJE Style

Satoskar AA, Brodsky SV, Nadasdy GM, Nadasdy T. Arterial and Arteriolar Lesions in Renal Allografts: A Differential Diagnostic Approach. J Interdiscip Histopathol. (2014), [cited August 16, 2018]; 2(3): 121-134. doi:10.5455/jihp.20140708044111



Harvard Style

Satoskar, A. A., Brodsky, S. V., Nadasdy, G. M. & Nadasdy, T. (2014) Arterial and Arteriolar Lesions in Renal Allografts: A Differential Diagnostic Approach. J Interdiscip Histopathol, 2 (3), 121-134. doi:10.5455/jihp.20140708044111



Turabian Style

Satoskar, Anjali A, Sergey V Brodsky, Gyongyi M Nadasdy, and Tibor Nadasdy. 2014. Arterial and Arteriolar Lesions in Renal Allografts: A Differential Diagnostic Approach. Journal of Interdisciplinary Histopathology, 2 (3), 121-134. doi:10.5455/jihp.20140708044111



Chicago Style

Satoskar, Anjali A, Sergey V Brodsky, Gyongyi M Nadasdy, and Tibor Nadasdy. "Arterial and Arteriolar Lesions in Renal Allografts: A Differential Diagnostic Approach." Journal of Interdisciplinary Histopathology 2 (2014), 121-134. doi:10.5455/jihp.20140708044111



MLA (The Modern Language Association) Style

Satoskar, Anjali A, Sergey V Brodsky, Gyongyi M Nadasdy, and Tibor Nadasdy. "Arterial and Arteriolar Lesions in Renal Allografts: A Differential Diagnostic Approach." Journal of Interdisciplinary Histopathology 2.3 (2014), 121-134. Print. doi:10.5455/jihp.20140708044111



APA (American Psychological Association) Style

Satoskar, A. A., Brodsky, S. V., Nadasdy, G. M. & Nadasdy, T. (2014) Arterial and Arteriolar Lesions in Renal Allografts: A Differential Diagnostic Approach. Journal of Interdisciplinary Histopathology, 2 (3), 121-134. doi:10.5455/jihp.20140708044111





Most Viewed Articles
  • Prevalence of Anemia and Associated Risk Factors among Pregnant Women Attending Antenatal Care in Azezo Health Center Gondar Town, Northwest Ethiopia
    Meseret Alem, Bamlaku Enawgaw, Aschalew Gelaw, Tigist Kenaw, Mohamed Seid , Yadesa Olkeba
    J Interdiscip Histopathol. 2013; 1(3): 137-144
    » Abstract & References » doi: 10.5455/jihp.20130122042052

  • Cytomorphometric Analysis of Oral Premalignant and Malignant Lesions Using Feulgen Stain and Exfoliative Brush Cytology.
    Priya Shirish Joshi, Manasi Sandipak Kaijkar
    J Interdiscip Histopathol. 2013; 1(4): 204-211
    » Abstract & References » doi: 10.5455/jihp.20130214064844

  • Differences in the Angiogenesis of Benign and Malignant Surface Epithelial Ovarian Tumors Demonstrated by Microvessel Density and Immunohistochemistry
    Shelly Sehgal, Prashant Goyal, Reena Agarwal, Sompal Singh, Awanindra Kumar, Ruchika Gupta, Vinita Kumar, Dipti Agrawal
    J Interdiscip Histopathol. 2013; 1(3): 145-152
    » Abstract & References » doi: 10.5455/jihp.20130204114930

  • The Role of CD10 Immunohistochemistry in the Grading of Phyllodes Tumour of The Breast
    Huzlinda Hussin,Jayalakshmi Pailoor, Peh Suat Cheng
    J Interdiscip Histopathol. 2013; 1(4): 195-203
    » Abstract & References » doi: 10.5455/jihp.20130307011432

  • Retroperitoneal Non-functioning Paraganglioma: A Case Report
    Faten Limaiem, Saadia Bouraoui, Sirine Bouslama, Sana Ben Slama, Ahlem Lahmar, Sabeh Mzabi-Regaya
    J Interdiscip Histopathol. 2013; 1(3): 168-171
    » Abstract & References » doi: 10.5455/jihp.20130115114630

  • P53 Immunohistochemical Staining Patterns in Benign, Premalignant and Malignant Lesions of the Oral Cavity: A Study of 68 Cases
    Pankaj Baweja, Vidya Monappa, Geetha Krishnanand
    J Interdiscip Histopathol. 2013; 1(3): 113-120
    » Abstract & References » doi: 10.5455/jihp.20130121120725

  • Nonspecific Cecal Ulcer: An Obsolete Jargon
    Duvuru Ram, Vilvapathy Senguttuvan Karthikeyan, Sarath Chandra Sistla
    J Interdiscip Histopathol. 2013; 1(2): 85-88
    » Abstract & References » doi: 10.5455/jihp.20121228043742

  • Histopathology as diagnostic tool for Ascosphaera apis infection in apparently healthy honey bees (Apis mellifera ligustica)
    Paola Maiolino, Francesca Carella, Giovanna De Leva, Laura Rinaldi, Giuseppe Cringoli, Manuela Martano
    J Interdiscip Histopathol. 2013; 1(3): 160-162
    » Abstract & References » doi: 10.5455/jihp.20130128010436

  • Double-Hit Lymphoma Presenting as Primary Renal Lymphoma: A Case Report
    Vikas Mehta, Chad Ellimottil, Jodi Speiser, Milind Velankar, Guliz A Barkan
    J Interdiscip Histopathol. 2013; 1(2): 93-97
    » Abstract & References » doi: 10.5455/jihp.20130121075815

  • Lateral Periodontal Cyst: A Report of Two Cases with Varying Clinico-Radiological Features
    Preethi Balan, Subhas G Babu, Shishir Shetty, Deepa Dsouza
    J Interdiscip Histopathol. 2012; 1(1): 41-44
    » Abstract & References » doi: 10.5455/jihp.20120808010902

  • Most Downloaded
  • Prevalence of Anemia and Associated Risk Factors among Pregnant Women Attending Antenatal Care in Azezo Health Center Gondar Town, Northwest Ethiopia
    Meseret Alem, Bamlaku Enawgaw, Aschalew Gelaw, Tigist Kenaw, Mohamed Seid , Yadesa Olkeba
    J Interdiscip Histopathol. 2013; 1(3): 137-144
    » Abstract & References » doi: 10.5455/jihp.20130122042052

  • Cytomorphometric Analysis of Oral Premalignant and Malignant Lesions Using Feulgen Stain and Exfoliative Brush Cytology.
    Priya Shirish Joshi, Manasi Sandipak Kaijkar
    J Interdiscip Histopathol. 2013; 1(4): 204-211
    » Abstract & References » doi: 10.5455/jihp.20130214064844

  • P53 Immunohistochemical Staining Patterns in Benign, Premalignant and Malignant Lesions of the Oral Cavity: A Study of 68 Cases
    Pankaj Baweja, Vidya Monappa, Geetha Krishnanand
    J Interdiscip Histopathol. 2013; 1(3): 113-120
    » Abstract & References » doi: 10.5455/jihp.20130121120725

  • Small Cell Lung Carcinoma: Better Than Its Reputation? A Population Based Study
    Hans Rostad, Erik Heyerdahl Strom, Helge Scott, Maria Ramnefjell, Kjell Kjellevold
    J Interdiscip Histopathol. 2012; 1(1): 1-4
    » Abstract & References » doi: 10.5455/jihp.20120703032839

  • Stented Vessels: A Challenge for Histological Preparation and Microscopy
    Andrea Nolte, Theresa Braun, Sven Zur Oven Krockhaus, Adelheid Munz, Ulrich Vogel, Christian Schlensak, Hans Wendel, Tobias Walker
    J Interdiscip Histopathol. 2013; 1(3): 104-112
    » Abstract & References » doi: 10.5455/jihp.20130306112937

  • Histopathology of the Liver Following Administration of Artesunate in Adult Wistar Rats
    Felix Monday Onyije, Josiah S Hart
    J Interdiscip Histopathol. 2012; 1(1): 26-29
    » Abstract & References » doi: 10.5455/jihp.20120606081137

  • Role of HPV Vaccine in the Prevention of Cervical Cancer
    Saleh JA, Yusuph H, Zailani ZB
    J Interdiscip Histopathol. 2013; 1(4): 212-216
    » Abstract & References » doi: 10.5455/jihp.20130119122700

  • Lateral Periodontal Cyst: A Report of Two Cases with Varying Clinico-Radiological Features
    Preethi Balan, Subhas G Babu, Shishir Shetty, Deepa Dsouza
    J Interdiscip Histopathol. 2012; 1(1): 41-44
    » Abstract & References » doi: 10.5455/jihp.20120808010902

  • Histopathological Effects of Varied Fluoride Concentration on Cerebrum in Albino Rats
    Sajad Hamid, Zaffar Kawoosa, Shahnawaz Hamid, M.A. Mir, Athar Hafiz, Irfan Jan, Fayiza Yaqoob
    J Interdiscip Histopathol. 2012; 1(1): 30-34
    » Abstract & References » doi: 10.5455/jihp.20121105123701

  • The Role of CD10 Immunohistochemistry in the Grading of Phyllodes Tumour of The Breast
    Huzlinda Hussin,Jayalakshmi Pailoor, Peh Suat Cheng
    J Interdiscip Histopathol. 2013; 1(4): 195-203
    » Abstract & References » doi: 10.5455/jihp.20130307011432

  • Most Cited Articles
  • Prevalence of Anemia and Associated Risk Factors among Pregnant Women Attending Antenatal Care in Azezo Health Center Gondar Town, Northwest Ethiopia
    Meseret Alem, Bamlaku Enawgaw, Aschalew Gelaw, Tigist Kenaw, Mohamed Seid , Yadesa Olkeba
    J Interdiscip Histopathol. 2013; 1(3): 137-144
    » Abstract & References » doi: 10.5455/jihp.20130122042052
    Cited : 19 times [Click to see citing articles]

  • Renal Biopsy for Research: An Overview of Russian Experience
    Sergei V. Jargin
    J Interdiscip Histopathol. 2014; 2(2): 88-95
    » Abstract & References » doi: 10.5455/jihp.20140312020838
    Cited : 4 times [Click to see citing articles]

  • Cadmium-Induced Testicular Toxicity, Oxidative Stress and Histopathology in Wistar Rats: Sustained Effects of Polyphenol-Rich Extract of Vernonia Amygdalina (Del.) Leaf
    Christian Eseigbe Imafidon, Olatoye Taiwo Risikat, Bamidele Funminiyi Samuel, Ojo Opeyemi Esther, Ademoye Kehinde Aderonke
    J Interdiscip Histopathol. 2016; 4(3): 54-62
    » Abstract & References » doi: 10.5455/jihp.20160618041629
    Cited : 4 times [Click to see citing articles]

  • Characterization of the Blood Brain Barrier in Pediatric Central Nervous System Neoplasms
    Christopher S Hong, Winson Ho, Martin G Piazza, Abhik Ray-Chaudhury, Zhengping Zhuang, John D Heiss
    J Interdiscip Histopathol. 2016; 4(2): 29-33
    » Abstract & References » doi: 10.5455/jihp.20160623053540
    Cited : 4 times [Click to see citing articles]

  • The Senescence Process of Internal Thoracic Artery
    Antonio Manenti, Luca Roncati, Giuseppe Barbolini, Francesco Rivasi
    J Interdiscip Histopathol. 2013; 1(2): 58-61
    » Abstract & References » doi: 10.5455/jihp.20121211115233
    Cited : 3 times [Click to see citing articles]

  • Primary Biliary Cirrhosis Overlapping with Autoimmune Hepatitis in an HIV-Infected Patient on Antiretroviral Therapy
    Margaret Rae Caplan, Apurva Trivedi, Mary McLaughlin, Annick Hebou, David Kleiner, Theo Heller, Caryn Morse
    J Interdiscip Histopathol. 2013; 1(5): 270-273
    » Abstract & References » doi: 10.5455/jihp.20130624104921
    Cited : 3 times [Click to see citing articles]

  • Evaluation of Amelotin Expression in Benign Odontogenic Tumors
    Daiana Paula Stolf, Tae-Young Lee, Grace Bradley, Bernhard Ganss
    J Interdiscip Histopathol. 2013; 1(5): 236-245
    » Abstract & References » doi: 10.5455/jihp.20130506045106
    Cited : 2 times [Click to see citing articles]

  • Diffuse Cutaneous Leishmaniasis in an HIV Sero-Positive Patient - A Diagnostic Dilemma
    Kumar U Mahesh, Balasaheb Ramling Yelikar, Ratnakar Madhav Rao Potekar, Palin Aparna, Murthy Keshav
    J Interdiscip Histopathol. 2012; 1(1): 45-47
    » Abstract & References » doi: 10.5455/jihp.20121109060828
    Cited : 2 times [Click to see citing articles]

  • Small Cell Lung Carcinoma: Better Than Its Reputation? A Population Based Study
    Hans Rostad, Erik Heyerdahl Strom, Helge Scott, Maria Ramnefjell, Kjell Kjellevold
    J Interdiscip Histopathol. 2012; 1(1): 1-4
    » Abstract & References » doi: 10.5455/jihp.20120703032839
    Cited : 2 times [Click to see citing articles]

  • Association of Claudin-1 with E-Cadherin/Catenin Complex, Microvessel Density (MVD)-Related Markers, and Clinicopathological Features in Colorectal Carcinoma
    Urania Skoufi, Dimitrios L Arvanitis, Litsa Lampri, Elli Ioachim, Jim Koutsogiannis, Christina Skoufi, Dimitris Tsironis and Antigony Mitselou
    J Interdiscip Histopathol. 2014; 2(3): 135-144
    » Abstract & References » doi: 10.5455/jihp.20140429121735
    Cited : 2 times [Click to see citing articles]