E-ISSN 2146-8362
 

Original Research 


Association of Claudin-1 with E-Cadherin/Catenin Complex, Microvessel Density (MVD)-Related Markers, and Clinicopathological Features in Colorectal Carcinoma

Urania Skoufi, Dimitrios L Arvanitis, Litsa Lampri, Elli Ioachim, Jim Koutsogiannis, Christina Skoufi, Dimitris Tsironis and Antigony Mitselou.

Cited by (2)

Abstract
Objectives: Intercellular adhesion mediated by claudin and cadherin/catenin complex is a prerequisite of epithelial integrity and differentiation and has been suggested to be frequently disturbed in cancers. Endoglin (CD105) has been shown to be a more useful marker to identify proliferating endothelium involved in angiogenesis than pan-endothelial markers such as CD31. The aim of this study was to assess the relationship between these markers and clinicopathological features of colorectal carcinomas.
Materials and Methods: Surgical specimens from 69 patients with colorectal cancer were immunostained for claudin-1, E-cadherin, β-catenin, endoglin and CD31.
Results: Forty-six (66.7%), 67 (97.1%), and 67 (97.1%) of the tumors, expressed immunostaining for claudin-1, E-cadherin and β-catenin, respectively. A significant association was seen between claudin-1 and E-cadherin expression (p=0.002), as well with β-catenin (p=0.009). High β-catenin expression appeared to reduce the risk of poor outcome. Endoglin vessel expression was correlated significantly with vessel invasion (p<0.0001), lymph node metastases (p=0.039), liver metastases (p<0.0001) and recurrence of the disease (p<0.010). Endoglin tumor cell expression was associated with E-cadherin and β-catenin expression (p=0.001 and p=0.068), but not with claudin-1 expression (p=0.299).
Conclusions: Loss of the expression of claudin-1, E-cadherin/β-catenin downregulation, and high CD105-MVD counts may play a significant role in the high incidence of angiolymphatic invasion, metastases and prognosis in colorectal-cancer patients, but further studies are needed to clearly define their role in colorectal carcinoma.

Key words: Colorectal cancer, claudin-1, E-cadherin, b-catenin, endoglin, CD31, immunohistochemistry


 
ARTICLE TOOLS
Abstract
PDF Fulltext
Print this article Print this Article
How to cite this articleHow to cite this article
Citation Tools
Related Records
 Articles by Urania Skoufi
Articles by Dimitrios L Arvanitis
Articles by Litsa Lampri
Articles by Elli Ioachim
Articles by Jim Koutsogiannis
Articles by Christina Skoufi
Articles by Dimitris Tsironis and Antigony Mitselou
on Google
on Google Scholar
Article Statistics
 Viewed: 1979
Downloaded: 516
Cited: 2

REFERENCES
1. Gonzalez-Mariscal L, Betanzos A, Nava P, Jaramillo BE. Tight junction proteins. ProgBiophysMolBiol 2003; 81:1-44. [DOI via Crossref]   
2. Tsukita S, Furuse M, Itoh M. Multifunctional strands in tight junctions. Nat Rev Mol Cell Biol 2001; 2: 285-293. [DOI via Crossref]    [Pubmed]   
3. Furuse M, Sasaki H, Fujimoto K, Tsukita S. A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occluding in fibroblasts. J Cell Biol 1998; 143: 391-401. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
4. Soler AP, miller RD, Laughlin KV, Carp NZ, Klurfeld DM, Mullin JM. Increased tight permeability is associated with the development of colon cancer. Carcinogenesis 1999; 20: 1425-1431. [DOI via Crossref]    [Pubmed]   
5. Martin TA, Jiang WG. Tight junctions and their role in cancer metastasis. HistolHistopathol 2001; 16: 1183-1195. [Pubmed]   
6. Peto J. Cancer epidemiology in the last century and the next decade. Nature 2001; 411: 390-395. [DOI via Crossref]    [Pubmed]   
7. Riddell RH, Petras RE, Williams GT, Sobin LH. Tumors of the Intestines (Atlas of Tumor Pathology (AFIP) 3rd Series) American Registry of Pathology, Washington DC, pp 133-189, 2002.
8. Tokes AM, Kulka J, Paku S, Szik A, Packa C, Novak PK, Szilak K, Kiss A, Schaff A. Claudin-1, -3, and -4 proteins and mRNA expression in benign and malignant breast lesions: a research study. Breast Cancer Res 2005; 7: 296-305. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
9. Tsukuhara M, Nagai H, Karmiakito T, Kawata H, Takayashiki N, Saito K, Tanaka A. Distinct expression pattern of claudin-1 and claudin -4 in intraductal papillary mucinous tumors of the pancreas. PatholInt 2005; 55: 63-69. [DOI via Crossref]    [Pubmed]   
10. Resnick MB, Konkin T, Routhier J, Sabo E, Pricolo VE. Claudin-1 is a strong prognostic indicator in stage II colonic cancer: a tissue microarray study. Mod Pathol 2005; 18: 511-518. [DOI via Crossref]    [Pubmed]   
11. Matsuoka T, Mitomi H, Fukui N, Kanazawa H, Saito T, Hayashi T, Yao T. Cluster analysis of claudin-1 and -4, E-cadherin, and b-catenin expression in colorectal cancer. J SurgOncol 2011; 103: 674-686. [DOI via Crossref]    [Pubmed]   
12. Yoshida T, Kinugasa T, Akagi Y, Kawahara A, Romeo K, Shiratsuchi I, Riju Y, Gaotanda Y, Shirouzu K. Decreased expression of claudin-1 in rectal cancer: a factor for recurrence and poor prognosis. Anticancer Res 2011; 31: 2517-2525. [Pubmed]   
13. Shibutani M, Noda E, Maeda K, Nagahara H, Ohtani H, Hirakawa K. Low expression of claudi-1 and presence of poorly differentiated tumor clusters correlate wit poor prognosis in colorectal cancer. Anticancer Res 2013; 33: 3301-3306. [Pubmed]   
14. Iacobuzio-Donahue CA, Maitra A, Shen-Ong GI, van Heek T, Ashfaq R, Meyer R, Walter K, Berg K, Hollingsworth MA, Cameron JL, Yeo CJ, Kern SE, Goggins M, Hruban RH. Discovery of novel tumor markers of pancreatic cancer using global gene expression technology. Am J Pathol 2002; 160: 1239-1249. [DOI via Crossref]   
15. Fluge O, Bruland O, Akslen LA, Lillehaug JR, Varlang JE. Gene expression in poorly differentiated thyroid carcinomas. Thyroid 2006; 16: 161-175. [DOI via Crossref]    [Pubmed]   
16. deOliveria SS, de Oliveria IM, DeSouza V, Morgado-Diaz JA. Claudins: up-regulation in human colorectal cancer. FEBS Lett 2005; 279: 6179-61-85.
17. Gröne J, Weber B, Staub E, Heinze M, Klaman I, Pilarsky C, Hermann K, Castanos-Velez E, Röpcke S, Mann B, Rosenthal A, Buhr HJ. Differential expression of genes encoding tight junction proteins in colorectal cancer: frequent dysregulation of claudin-1, -8, and -12. Int J Colorectal Dis 2007; 22: 651-659. [DOI via Crossref]    [Pubmed]   
18. Huo Q, Kinugasa T, Wang L, Huang J, Zhao J, Shibaguchi H, Kuroki M, Tanaka T, Yamashita Y, Nabeshima K, Iwasaki H, Kuroki M. Claudin-1 protein involved in the tumorigenesis of colorectal cancer. Anticancer Res 2009; 29: 851-858. [Pubmed]   
19. Mess ST Mennigen R, Spicker T, Rijcken E, Senninger N, Hafer J, Bruewer M. Expression of tight and adherens junction proteins in ulcerative colitis associated colorectal carcinoma: upregulation of claudin -1, claudin-3, claudin-4 and β-catenin. Int J Colorectal Dis 2009; 24: 361-368. [DOI via Crossref]    [Pubmed]   
20. Bezdekova M, Brychtova S, Sedlakova E, Langova K, Brychta T, Belej K. Analysis of Snail-1, E-cadherin and claudin-1 expression in colorectal adenomas and carcinomas. Int J MolSci 2012; 13: 1632-1643. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
21. Niessen CM, Gottardi CJ. Molecular components of the adherens junctions. BiochemBiophysActa 2008; 1778: 562-571.
22. Wheelock MJ, Johnson KR. Cadherins as modulators of cellular phenotype. Annu Rev Cell Dev Biol 2003; 19: 207-235. [DOI via Crossref]    [Pubmed]   
23. vanAken E, De Wever O, Correia de Rocha AS, Marcel M. Defective E-cadherin/catenin complexes in human cancer. VirchowsAech 2001; 439: 725-731. [DOI via Crossref]   
24. Takayama T, Shiozaki H, Shibamoto S, Oka H, Kimura Y, Tamura S, Inoue M, Monden T, Ito F, Monden M. Beta-catenin expression in human cancers. Am J Pathol 1996; 148: 39-46. [Pubmed]    [PMC Free Fulltext]   
25. Hiscox S, Jiang WG. Expression of E-cadherin, alpha, beta and gamma catenin in human colorectal cancer. Anticancer Res 1997; 17: 1349-1354. [Pubmed]   
26. Ghadimi BM, Behren J, Hoffmann I, Haeusch W, Birchmeier W, Schlag PM. Immunohistological analysis of E-cadherin, alpha-, beta- and gamma-catenin expression in colorectal cancer: implication for cell adhesion and signaling. Eur J Cancer 1999; 35: 60-65. [DOI via Crossref]   
27. Takeichi M. Cadherins in cancer: implications for invasion and metastasis. CurrOpin Cell Biol 1993; 5: 806-811. [DOI via Crossref]   
28. Logan CY, Nusse R. The Wnt signaling pathway in development and disease. Ann Rev Cell Dev Biol 2004; 20: 781-810. [DOI via Crossref]    [Pubmed]   
29. Duff SE, Ki C, Garland JM, Kumar S. CD105 is important for angiogenesis: evidence and potential applications. FASEB J 2003; 17: 984-992. [DOI via Crossref]    [Pubmed]   
30. Akagi K, Ikeda Y, Sumiyoshi Y, Kimura Y, Kinoshita J, Miyazaki M, Abe T. Estimation of angiogenesis with anti-CD105 immunostaining in the process of colorectal cancer development. Surgery 2002; 131: S109-S113. [DOI via Crossref]    [Pubmed]   
31. Fonsatti E, Sigalotti L, Arslan P, Altomonte M, Maio M. Emerging role of endoglin (CD105) as a marker of angiogenesis with clinical potential in human malignancies. Curr Cancer Drug Targets 2003; 3: 427-432. [DOI via Crossref]    [Pubmed]   
32. Saad RS, Liu YL, Nathan G, Celebrezze J, Medich D, Silverman JF. Endoglin (CD105) a vascular endothelial growth factor as a prognostic marker in colorectal cancer. Mod Pathol 2004; 17: 197-203. [DOI via Crossref]    [Pubmed]   
33. Romani AN, Borghetti AF, Del Rio P, Sianesi M, Soliani P. The risk of developing metastatic disease in colorectal cancer. J SurgOncol 2006; 93: 446-455. [DOI via Crossref]    [Pubmed]   
34. Hamilton SR, Honen A. Pathology and genetics tumors of the digestive system. World Health Organization Classification of Tumors. IARC Press, Lyon, 2000.
35. Dukes CE, Bussey HJR. The spread of rectal cancer and its effect in prognosis. Br J Cancer 1958; 12: 309-320. [DOI via Crossref]   
36. Cascinu S, Georgoulias V, Kerr D, Manghan T, Labianca R, Ychou M. Colorectal cancer in the adjuvant setting: perspectives on treatment and the role of prognostic factors. AnnuOncol 2003; 14 Suppl2 :ii25-ii29.
37. Mitselou A, Ioachim E, Skoufi U, Tsironis D, Nesseris I, Lampri E, Vougiouklakis T, Briassoulis E, Arvanitis LA. Association between thrombospondin-1, angiogenesis related markers, and extracellular matrix components with colorectal cancer outcome. The Open Journal of Colorectal Cancer 2012, 5:38-46
38. Mitselou A, Skoufi U, Briasoulis E, Arvanitis D, Vougiouklakis T, Tsimofiannis KE, Ioachim E. Association of syndecan-1 with angiogenesis related markers, extracellular matrix components, and clinicopathological features in colorectal carcinoma. Anticancer Res 32: 3977-3985, 2012. [Pubmed]   
39. Mitselou A, Ioachim E, Skoufi U, Tsironis C, Tsimogiannis K E., Skoufi C, Vougiouklakis T, Briasoulis E. Predictive Role of Thymidine Phosphorylase Expression in Patients with Colorectal Cancer and its Association with Angiogenesis-related Proteins and Extracellular Matrix Components. In vivo 26: 1057-1068, 2012. [Pubmed]   
40. Dhawan P, Singh AB, Deane NG, No YR, Shiou SR, Schmidt C, Neff J, Washington MK and Beauchamp RD. Claudin-1 regulates cellular transformation and metastatic behavior in colon cancer. J Clin Invest 2005; 115: 1765-1776. [DOI via Crossref]    [Pubmed]    [PMC Free Fulltext]   
41. Ersoz S, Mungan S, Cobanoglu U, Turgutalp H, Ozoran Y. Prognostic importance of Claudin-1 and Claudin-4 expression in colon carcinomas. Pathol Res Prac 2011; 201: 285-289. [DOI via Crossref]    [Pubmed]   
42. Elzagheid A, Buhmeida A, Laato M, El-Faitori O, Syrjanen K, Collan Y, Pyrhonen S. Loss of E-cadherin expression predicts disease recurrence and shorter survival in colorectal carcinoma. APMIS 2012; 120: 539-548. [DOI via Crossref]    [Pubmed]   
43. Buhmeida A, Elzagheid A, Algais A. Expression of the cell-cell adhesion molecule β-catenin in colorectal carcinoma and their metastasis. APMIS 2008; 116: 1-9. [DOI via Crossref]    [Pubmed]   
44. Hörkkö TT, Klintrup K, Mäkinen JM, Näpänkangas JB, Tuominen HJ, Mäkelä J, Karttunen TJ, Mäkinen MJ. Budding invasive margin and prognosis in colorectal cancer-no direct association with beta catenin expression. Eur J Cancer 2006; 42: 964-971. [DOI via Crossref]    [Pubmed]   
45. Lugli A, Zlobec I, Minoo P, Baker K, Tornillo L, Terraciano L, Jass JR. Prognostic significance of the wnt signaling pathway molecules APC, beta-catenin and E-cadherin in colorectal cancer: a tissue microarray-based analysis. Histopathology 2007; 50: 453-464. [DOI via Crossref]    [Pubmed]   
46. Wong SCC, Lo ESF, Chan AKC, Lee KC, Hsiao WL. Nuclear beta catenin as a potential prognostic marker in patients with colorectal cancer from Hong Kong. J ClinPatholMolPathol 2003; 56: 347-352.
47. Chung GG, Provost E, Kielhorn EP, Charette LA, Smith BL, Rimm DL. Tissue microarray analysis of β-catenin in colorectal cancer shows nuclear phosphor-β-catenin is associated with a better prognosis. Clin Cancer Res 2001; 7: 4013-4020. [Pubmed]   
48. Minhajat R, Mori D, Yamasaki F, Sugita Y, Satoh T, Tokunaga O. Endoglin (CD105) expression in angiogenesis of colon cancer: analysis using tissue microarrays and comparison with other endothelial markers. Virchows Arch 2006; 448: 127-134. [DOI via Crossref]    [Pubmed]   
49. Choi HJ, Hyun MS, Jung GJ, Kim SS, Hong SH. Tumor angiogenesis as a predictor in colorectal carcinoma with special reference to mode of metastasis and recurrence. Oncology 1998; 55: 575-581. [DOI via Crossref]    [Pubmed]   
50. Bellone G, Granigui C, Vizio C, Mauri FA, Prati A, Solero D, Dughera L, Ruffini E, Gasparri G, Camandona M. Abnormal expression of endoglin and its receptor complex (TGF-β1 and TGF-β receptor II) as early angiogenic switch indicator in premalignant lesions of the colon mucosa. Int J Oncol 2010; 37: 1153-1165. [DOI via Crossref]    [Pubmed]   
51. Liu Y, Jovanovic B, Pins M, Lee C, Bergan RC. Overexpression of endoglin in human prostate cancer suppresses cell detachment, migration and invasion. Oncogene 2002; 21: 8272-8281. [DOI via Crossref]    [Pubmed]   
52. Takahashi N, Kawanishi-Tabata R, Haba A Tabata H, Haruta Y, Tsai H, Sean BK. Association of serum endoglin with metastasis in patients with colorectal, breast, and other tumors, and suppressive effect of chemotherapy on the serum endoglin. Clin Cancer Res 2001; 7: 524-532. [Pubmed]   

This Article Cited By the following articles

Recurrences in stage II rectal carcinoma after curative resection alone: from the viewpoint of angiogenesis
World J Surg Onc 2016; 14(1): .

1
 
Prognostic Significance of Microvessel Density Determining by Endoglin in Stage II Rectal Carcinoma: A Retrospective Analysis
Gastroenterology Research and Practice 2015; 2015(): 1.

2
 
How to Cite this Article
Pubmed Style

Skoufi U, Arvanitis DL, Lampri L, Ioachim E, Koutsogiannis J, Skoufi C, Mitselou DTaA. Association of Claudin-1 with E-Cadherin/Catenin Complex, Microvessel Density (MVD)-Related Markers, and Clinicopathological Features in Colorectal Carcinoma. J Interdiscip Histopathol. 2014; 2(3): 135-144. doi:10.5455/jihp.20140429121735


Web Style

Skoufi U, Arvanitis DL, Lampri L, Ioachim E, Koutsogiannis J, Skoufi C, Mitselou DTaA. Association of Claudin-1 with E-Cadherin/Catenin Complex, Microvessel Density (MVD)-Related Markers, and Clinicopathological Features in Colorectal Carcinoma. http://www.ejmjih.com/?mno=156920 [Access: October 18, 2018]. doi:10.5455/jihp.20140429121735


AMA (American Medical Association) Style

Skoufi U, Arvanitis DL, Lampri L, Ioachim E, Koutsogiannis J, Skoufi C, Mitselou DTaA. Association of Claudin-1 with E-Cadherin/Catenin Complex, Microvessel Density (MVD)-Related Markers, and Clinicopathological Features in Colorectal Carcinoma. J Interdiscip Histopathol. 2014; 2(3): 135-144. doi:10.5455/jihp.20140429121735



Vancouver/ICMJE Style

Skoufi U, Arvanitis DL, Lampri L, Ioachim E, Koutsogiannis J, Skoufi C, Mitselou DTaA. Association of Claudin-1 with E-Cadherin/Catenin Complex, Microvessel Density (MVD)-Related Markers, and Clinicopathological Features in Colorectal Carcinoma. J Interdiscip Histopathol. (2014), [cited October 18, 2018]; 2(3): 135-144. doi:10.5455/jihp.20140429121735



Harvard Style

Skoufi, U., Arvanitis, D. L., Lampri, L., Ioachim, E., Koutsogiannis, J., Skoufi, C. & Mitselou, D. T. a. A. (2014) Association of Claudin-1 with E-Cadherin/Catenin Complex, Microvessel Density (MVD)-Related Markers, and Clinicopathological Features in Colorectal Carcinoma. J Interdiscip Histopathol, 2 (3), 135-144. doi:10.5455/jihp.20140429121735



Turabian Style

Skoufi, Urania, Dimitrios L Arvanitis, Litsa Lampri, Elli Ioachim, Jim Koutsogiannis, Christina Skoufi, and Dimitris Tsironis and Antigony Mitselou. 2014. Association of Claudin-1 with E-Cadherin/Catenin Complex, Microvessel Density (MVD)-Related Markers, and Clinicopathological Features in Colorectal Carcinoma. Journal of Interdisciplinary Histopathology, 2 (3), 135-144. doi:10.5455/jihp.20140429121735



Chicago Style

Skoufi, Urania, Dimitrios L Arvanitis, Litsa Lampri, Elli Ioachim, Jim Koutsogiannis, Christina Skoufi, and Dimitris Tsironis and Antigony Mitselou. "Association of Claudin-1 with E-Cadherin/Catenin Complex, Microvessel Density (MVD)-Related Markers, and Clinicopathological Features in Colorectal Carcinoma." Journal of Interdisciplinary Histopathology 2 (2014), 135-144. doi:10.5455/jihp.20140429121735



MLA (The Modern Language Association) Style

Skoufi, Urania, Dimitrios L Arvanitis, Litsa Lampri, Elli Ioachim, Jim Koutsogiannis, Christina Skoufi, and Dimitris Tsironis and Antigony Mitselou. "Association of Claudin-1 with E-Cadherin/Catenin Complex, Microvessel Density (MVD)-Related Markers, and Clinicopathological Features in Colorectal Carcinoma." Journal of Interdisciplinary Histopathology 2.3 (2014), 135-144. Print. doi:10.5455/jihp.20140429121735



APA (American Psychological Association) Style

Skoufi, U., Arvanitis, D. L., Lampri, L., Ioachim, E., Koutsogiannis, J., Skoufi, C. & Mitselou, D. T. a. A. (2014) Association of Claudin-1 with E-Cadherin/Catenin Complex, Microvessel Density (MVD)-Related Markers, and Clinicopathological Features in Colorectal Carcinoma. Journal of Interdisciplinary Histopathology, 2 (3), 135-144. doi:10.5455/jihp.20140429121735





Most Viewed Articles
  • Prevalence of Anemia and Associated Risk Factors among Pregnant Women Attending Antenatal Care in Azezo Health Center Gondar Town, Northwest Ethiopia
    Meseret Alem, Bamlaku Enawgaw, Aschalew Gelaw, Tigist Kenaw, Mohamed Seid , Yadesa Olkeba
    J Interdiscip Histopathol. 2013; 1(3): 137-144
    » Abstract & References » doi: 10.5455/jihp.20130122042052

  • Cytomorphometric Analysis of Oral Premalignant and Malignant Lesions Using Feulgen Stain and Exfoliative Brush Cytology.
    Priya Shirish Joshi, Manasi Sandipak Kaijkar
    J Interdiscip Histopathol. 2013; 1(4): 204-211
    » Abstract & References » doi: 10.5455/jihp.20130214064844

  • Differences in the Angiogenesis of Benign and Malignant Surface Epithelial Ovarian Tumors Demonstrated by Microvessel Density and Immunohistochemistry
    Shelly Sehgal, Prashant Goyal, Reena Agarwal, Sompal Singh, Awanindra Kumar, Ruchika Gupta, Vinita Kumar, Dipti Agrawal
    J Interdiscip Histopathol. 2013; 1(3): 145-152
    » Abstract & References » doi: 10.5455/jihp.20130204114930

  • The Role of CD10 Immunohistochemistry in the Grading of Phyllodes Tumour of The Breast
    Huzlinda Hussin,Jayalakshmi Pailoor, Peh Suat Cheng
    J Interdiscip Histopathol. 2013; 1(4): 195-203
    » Abstract & References » doi: 10.5455/jihp.20130307011432

  • Retroperitoneal Non-functioning Paraganglioma: A Case Report
    Faten Limaiem, Saadia Bouraoui, Sirine Bouslama, Sana Ben Slama, Ahlem Lahmar, Sabeh Mzabi-Regaya
    J Interdiscip Histopathol. 2013; 1(3): 168-171
    » Abstract & References » doi: 10.5455/jihp.20130115114630

  • P53 Immunohistochemical Staining Patterns in Benign, Premalignant and Malignant Lesions of the Oral Cavity: A Study of 68 Cases
    Pankaj Baweja, Vidya Monappa, Geetha Krishnanand
    J Interdiscip Histopathol. 2013; 1(3): 113-120
    » Abstract & References » doi: 10.5455/jihp.20130121120725

  • Nonspecific Cecal Ulcer: An Obsolete Jargon
    Duvuru Ram, Vilvapathy Senguttuvan Karthikeyan, Sarath Chandra Sistla
    J Interdiscip Histopathol. 2013; 1(2): 85-88
    » Abstract & References » doi: 10.5455/jihp.20121228043742

  • Histopathology as diagnostic tool for Ascosphaera apis infection in apparently healthy honey bees (Apis mellifera ligustica)
    Paola Maiolino, Francesca Carella, Giovanna De Leva, Laura Rinaldi, Giuseppe Cringoli, Manuela Martano
    J Interdiscip Histopathol. 2013; 1(3): 160-162
    » Abstract & References » doi: 10.5455/jihp.20130128010436

  • Lateral Periodontal Cyst: A Report of Two Cases with Varying Clinico-Radiological Features
    Preethi Balan, Subhas G Babu, Shishir Shetty, Deepa Dsouza
    J Interdiscip Histopathol. 2012; 1(1): 41-44
    » Abstract & References » doi: 10.5455/jihp.20120808010902

  • Double-Hit Lymphoma Presenting as Primary Renal Lymphoma: A Case Report
    Vikas Mehta, Chad Ellimottil, Jodi Speiser, Milind Velankar, Guliz A Barkan
    J Interdiscip Histopathol. 2013; 1(2): 93-97
    » Abstract & References » doi: 10.5455/jihp.20130121075815

  • Most Downloaded
  • Prevalence of Anemia and Associated Risk Factors among Pregnant Women Attending Antenatal Care in Azezo Health Center Gondar Town, Northwest Ethiopia
    Meseret Alem, Bamlaku Enawgaw, Aschalew Gelaw, Tigist Kenaw, Mohamed Seid , Yadesa Olkeba
    J Interdiscip Histopathol. 2013; 1(3): 137-144
    » Abstract & References » doi: 10.5455/jihp.20130122042052

  • Cytomorphometric Analysis of Oral Premalignant and Malignant Lesions Using Feulgen Stain and Exfoliative Brush Cytology.
    Priya Shirish Joshi, Manasi Sandipak Kaijkar
    J Interdiscip Histopathol. 2013; 1(4): 204-211
    » Abstract & References » doi: 10.5455/jihp.20130214064844

  • P53 Immunohistochemical Staining Patterns in Benign, Premalignant and Malignant Lesions of the Oral Cavity: A Study of 68 Cases
    Pankaj Baweja, Vidya Monappa, Geetha Krishnanand
    J Interdiscip Histopathol. 2013; 1(3): 113-120
    » Abstract & References » doi: 10.5455/jihp.20130121120725

  • Histopathology of the Liver Following Administration of Artesunate in Adult Wistar Rats
    Felix Monday Onyije, Josiah S Hart
    J Interdiscip Histopathol. 2012; 1(1): 26-29
    » Abstract & References » doi: 10.5455/jihp.20120606081137

  • Lateral Periodontal Cyst: A Report of Two Cases with Varying Clinico-Radiological Features
    Preethi Balan, Subhas G Babu, Shishir Shetty, Deepa Dsouza
    J Interdiscip Histopathol. 2012; 1(1): 41-44
    » Abstract & References » doi: 10.5455/jihp.20120808010902

  • Stented Vessels: A Challenge for Histological Preparation and Microscopy
    Andrea Nolte, Theresa Braun, Sven Zur Oven Krockhaus, Adelheid Munz, Ulrich Vogel, Christian Schlensak, Hans Wendel, Tobias Walker
    J Interdiscip Histopathol. 2013; 1(3): 104-112
    » Abstract & References » doi: 10.5455/jihp.20130306112937

  • Small Cell Lung Carcinoma: Better Than Its Reputation? A Population Based Study
    Hans Rostad, Erik Heyerdahl Strom, Helge Scott, Maria Ramnefjell, Kjell Kjellevold
    J Interdiscip Histopathol. 2012; 1(1): 1-4
    » Abstract & References » doi: 10.5455/jihp.20120703032839

  • Role of HPV Vaccine in the Prevention of Cervical Cancer
    Saleh JA, Yusuph H, Zailani ZB
    J Interdiscip Histopathol. 2013; 1(4): 212-216
    » Abstract & References » doi: 10.5455/jihp.20130119122700

  • Histopathological Effects of Varied Fluoride Concentration on Cerebrum in Albino Rats
    Sajad Hamid, Zaffar Kawoosa, Shahnawaz Hamid, M.A. Mir, Athar Hafiz, Irfan Jan, Fayiza Yaqoob
    J Interdiscip Histopathol. 2012; 1(1): 30-34
    » Abstract & References » doi: 10.5455/jihp.20121105123701

  • The Role of CD10 Immunohistochemistry in the Grading of Phyllodes Tumour of The Breast
    Huzlinda Hussin,Jayalakshmi Pailoor, Peh Suat Cheng
    J Interdiscip Histopathol. 2013; 1(4): 195-203
    » Abstract & References » doi: 10.5455/jihp.20130307011432

  • Most Cited Articles
  • Prevalence of Anemia and Associated Risk Factors among Pregnant Women Attending Antenatal Care in Azezo Health Center Gondar Town, Northwest Ethiopia
    Meseret Alem, Bamlaku Enawgaw, Aschalew Gelaw, Tigist Kenaw, Mohamed Seid , Yadesa Olkeba
    J Interdiscip Histopathol. 2013; 1(3): 137-144
    » Abstract & References » doi: 10.5455/jihp.20130122042052
    Cited : 20 times [Click to see citing articles]

  • Renal Biopsy for Research: An Overview of Russian Experience
    Sergei V. Jargin
    J Interdiscip Histopathol. 2014; 2(2): 88-95
    » Abstract & References » doi: 10.5455/jihp.20140312020838
    Cited : 4 times [Click to see citing articles]

  • Cadmium-Induced Testicular Toxicity, Oxidative Stress and Histopathology in Wistar Rats: Sustained Effects of Polyphenol-Rich Extract of Vernonia Amygdalina (Del.) Leaf
    Christian Eseigbe Imafidon, Olatoye Taiwo Risikat, Bamidele Funminiyi Samuel, Ojo Opeyemi Esther, Ademoye Kehinde Aderonke
    J Interdiscip Histopathol. 2016; 4(3): 54-62
    » Abstract & References » doi: 10.5455/jihp.20160618041629
    Cited : 4 times [Click to see citing articles]

  • Characterization of the Blood Brain Barrier in Pediatric Central Nervous System Neoplasms
    Christopher S Hong, Winson Ho, Martin G Piazza, Abhik Ray-Chaudhury, Zhengping Zhuang, John D Heiss
    J Interdiscip Histopathol. 2016; 4(2): 29-33
    » Abstract & References » doi: 10.5455/jihp.20160623053540
    Cited : 4 times [Click to see citing articles]

  • Fine Architectonics and Protein Turnover Rate in Myofibrils of Glucocorticoid-Caused Myopathic Rats
    Priit Kaasik, Maria Umnova, Karin Alev, Anne Selart, Teet Seene
    J Interdiscip Histopathol. 2012; 1(1): 5-10
    » Abstract & References » doi: 10.5455/jihp.20120606081246
    Cited : 3 times [Click to see citing articles]

  • The Senescence Process of Internal Thoracic Artery
    Antonio Manenti, Luca Roncati, Giuseppe Barbolini, Francesco Rivasi
    J Interdiscip Histopathol. 2013; 1(2): 58-61
    » Abstract & References » doi: 10.5455/jihp.20121211115233
    Cited : 3 times [Click to see citing articles]

  • Primary Biliary Cirrhosis Overlapping with Autoimmune Hepatitis in an HIV-Infected Patient on Antiretroviral Therapy
    Margaret Rae Caplan, Apurva Trivedi, Mary McLaughlin, Annick Hebou, David Kleiner, Theo Heller, Caryn Morse
    J Interdiscip Histopathol. 2013; 1(5): 270-273
    » Abstract & References » doi: 10.5455/jihp.20130624104921
    Cited : 3 times [Click to see citing articles]

  • A Comparative Study of Oral Hamartoma and Choristoma
    Ilana Kaplan, Irit Allon, Benjamin Shlomi, Vadim Raiser, Dror M. Allon
    J Interdiscip Histopathol. 2015; 3(4): 129-134
    » Abstract & References » doi: 10.5455/jihp.20151020122441
    Cited : 3 times [Click to see citing articles]

  • Evaluation of Amelotin Expression in Benign Odontogenic Tumors
    Daiana Paula Stolf, Tae-Young Lee, Grace Bradley, Bernhard Ganss
    J Interdiscip Histopathol. 2013; 1(5): 236-245
    » Abstract & References » doi: 10.5455/jihp.20130506045106
    Cited : 2 times [Click to see citing articles]

  • Diffuse Cutaneous Leishmaniasis in an HIV Sero-Positive Patient - A Diagnostic Dilemma
    Kumar U Mahesh, Balasaheb Ramling Yelikar, Ratnakar Madhav Rao Potekar, Palin Aparna, Murthy Keshav
    J Interdiscip Histopathol. 2012; 1(1): 45-47
    » Abstract & References » doi: 10.5455/jihp.20121109060828
    Cited : 2 times [Click to see citing articles]