E-ISSN 2146-8362
 

Original Research 


Survivin Expression in Renal Epithelial Tumors: Its Usage in the Differential Diagnosis of Eosinophilic Renal Epithelial Tumors

Ayhan Ozcan, Nuri Yigit, Onder Onguru, Bilal Firat Alp, Sukru Ozaydin.

Abstract
Objective: The differential diagnosis of renal tumors can be problematic due to overlapping morphologic features. The purpose of this study was to assess the potential contribution of survivin expression in the differential diagnosis and determination of therapy modalities of these tumors.
Methods: This study consisted of 15 chromophobe (ChRCC), 15 clear cell (CCRCC) and 9 papillary (PRCC) renal cell carcinomas, and 13 oncocytomas. Sections were stained against survivin antibody.
Results: PRCCs and CCRCCs showed diffuse and strong survivin expression. Survivin expression was strikingly prominent in type1 PRCCs and cystic CCRCCs. In CCRCCs, survivin expression was more pronounced in low grade areas than high grade and sarcomatoid areas. In ChRCC, survivin expression was more limited and weaker than that of oncocytomas and other malignant renal tumors. In non-neoplastic renal tissue, survivin expression was more pronounced in podocytes and atrophic tubules than other nephron parts.
Conclusions: Our results suggested that survivin may helpful in the differential diagnosis of renal tumors despite limited number of our cases. Experimental studies have revealed that inhibition of survivin induces apoptosis and enhance radiosensitivity of RCC cells. Taken together, to be known the proportion of survivin expression in subtypes of renal tumors may contribute to determine new therapeutic strategies for RCCs. This needs to be proven in more wide series.

Key words: Kidney cancer; inhibitor apoptosis proteins; immunohistochemistry; differential diagnosis; therapy


 
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How to Cite this Article
Pubmed Style

Ozcan A, Yigit N, Onguru O, Alp BF, Ozaydin S. Survivin Expression in Renal Epithelial Tumors: Its Usage in the Differential Diagnosis of Eosinophilic Renal Epithelial Tumors. J Interdiscip Histopathol. 2014; 2(2): 69-73. doi:10.5455/jihp.20140312060341


Web Style

Ozcan A, Yigit N, Onguru O, Alp BF, Ozaydin S. Survivin Expression in Renal Epithelial Tumors: Its Usage in the Differential Diagnosis of Eosinophilic Renal Epithelial Tumors. http://www.ejmjih.com/?mno=152650 [Access: May 25, 2018]. doi:10.5455/jihp.20140312060341


AMA (American Medical Association) Style

Ozcan A, Yigit N, Onguru O, Alp BF, Ozaydin S. Survivin Expression in Renal Epithelial Tumors: Its Usage in the Differential Diagnosis of Eosinophilic Renal Epithelial Tumors. J Interdiscip Histopathol. 2014; 2(2): 69-73. doi:10.5455/jihp.20140312060341



Vancouver/ICMJE Style

Ozcan A, Yigit N, Onguru O, Alp BF, Ozaydin S. Survivin Expression in Renal Epithelial Tumors: Its Usage in the Differential Diagnosis of Eosinophilic Renal Epithelial Tumors. J Interdiscip Histopathol. (2014), [cited May 25, 2018]; 2(2): 69-73. doi:10.5455/jihp.20140312060341



Harvard Style

Ozcan, A., Yigit, N., Onguru, O., Alp, B. F. & Ozaydin, S. (2014) Survivin Expression in Renal Epithelial Tumors: Its Usage in the Differential Diagnosis of Eosinophilic Renal Epithelial Tumors. J Interdiscip Histopathol, 2 (2), 69-73. doi:10.5455/jihp.20140312060341



Turabian Style

Ozcan, Ayhan, Nuri Yigit, Onder Onguru, Bilal Firat Alp, and Sukru Ozaydin. 2014. Survivin Expression in Renal Epithelial Tumors: Its Usage in the Differential Diagnosis of Eosinophilic Renal Epithelial Tumors. Journal of Interdisciplinary Histopathology, 2 (2), 69-73. doi:10.5455/jihp.20140312060341



Chicago Style

Ozcan, Ayhan, Nuri Yigit, Onder Onguru, Bilal Firat Alp, and Sukru Ozaydin. "Survivin Expression in Renal Epithelial Tumors: Its Usage in the Differential Diagnosis of Eosinophilic Renal Epithelial Tumors." Journal of Interdisciplinary Histopathology 2 (2014), 69-73. doi:10.5455/jihp.20140312060341



MLA (The Modern Language Association) Style

Ozcan, Ayhan, Nuri Yigit, Onder Onguru, Bilal Firat Alp, and Sukru Ozaydin. "Survivin Expression in Renal Epithelial Tumors: Its Usage in the Differential Diagnosis of Eosinophilic Renal Epithelial Tumors." Journal of Interdisciplinary Histopathology 2.2 (2014), 69-73. Print. doi:10.5455/jihp.20140312060341



APA (American Psychological Association) Style

Ozcan, A., Yigit, N., Onguru, O., Alp, B. F. & Ozaydin, S. (2014) Survivin Expression in Renal Epithelial Tumors: Its Usage in the Differential Diagnosis of Eosinophilic Renal Epithelial Tumors. Journal of Interdisciplinary Histopathology, 2 (2), 69-73. doi:10.5455/jihp.20140312060341





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